PLA2G12A

Phospholipase A2, group XIIA
Identifiers
Symbols	PLA2G12A ; GXII; PLA2G12; ROSSY
External IDs	OMIM: 611652 MGI: 1913600 HomoloGene: 11328 ChEMBL: 6122 GeneCards: PLA2G12A Gene
EC number	3.1.1.4
Gene ontology Molecular function • calcium ion binding • calcium-dependent phospholipase A2 activity Cellular component • extracellular region • endoplasmic reticulum • Golgi apparatus Biological process • phospholipid metabolic process • phosphatidic acid biosynthetic process • biological_process • lipid catabolic process • phosphatidylglycerol acyl-chain remodeling • phosphatidylinositol acyl-chain remodeling • phosphatidylserine acyl-chain remodeling • phosphatidylcholine acyl-chain remodeling • phosphatidylethanolamine acyl-chain remodeling • small molecule metabolic process • glycerophospholipid biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81579	66350
Ensembl	ENSG00000123739	ENSMUSG00000027999
UniProt	Q9BZM1	Q9EPR2
RefSeq (mRNA)	NM_030821	NM_001286948
RefSeq (protein)	NP_110448	NP_001273877
Location (UCSC)	Chr 4: 109.71 – 109.73 Mb	Chr 3: 129.88 – 129.9 Mb
PubMed search

Group XIIA secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G12A gene.^[1][2]

References

1. Gelb MH, Valentin E, Ghomashchi F, Lazdunski M, Lambeau G (Jan 2001). "Cloning and recombinant expression of a structurally novel human secreted phospholipase A2". J Biol Chem 275 (51): 39823–6. doi:10.1074/jbc.C000671200. PMC 3422575. PMID 11031251.
2. "Entrez Gene: PLA2G12A phospholipase A2, group XIIA".

Further reading

• Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.". Neurotoxicology 19 (4–5): 683–8. PMID 9745929.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rouault M, Bollinger JG, Lazdunski M, et al. (2003). "Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity". Biochemistry 42 (39): 11494–503. doi:10.1021/bi0349930. PMID 14516201.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Murakami M, Masuda S, Shimbara S, et al. (2003). "Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII)". J. Biol. Chem. 278 (12): 10657–67. doi:10.1074/jbc.M211325200. PMID 12522102.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ho IC, Arm JP, Bingham CO, et al. (2001). "A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells". J. Biol. Chem. 276 (21): 18321–6. doi:10.1074/jbc.M008837200. PMID 11278438.
• Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.