PLA2G4C

Phospholipase A2, group IVC (cytosolic, calcium-independent)
Identifiers
Symbols	PLA2G4C ; CPLA2-gamma
External IDs	OMIM: 603602 MGI: 1196403 HomoloGene: 115256 IUPHAR: 1426 ChEMBL: 4834 GeneCards: PLA2G4C Gene
EC number	3.1.1.4
Gene ontology Molecular function • phospholipid binding • calcium-independent phospholipase A2 activity Cellular component • nuclear envelope • nucleoplasm • endoplasmic reticulum membrane • cytosol • cell cortex • membrane Biological process • phospholipid metabolic process • inflammatory response • parturition • arachidonic acid metabolic process • intracellular signal transduction • phosphatidylinositol acyl-chain remodeling • phosphatidylcholine acyl-chain remodeling • phosphatidylethanolamine acyl-chain remodeling • small molecule metabolic process • glycerophospholipid biosynthetic process • glycerophospholipid catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8605	232889
Ensembl	ENSG00000105499	ENSMUSG00000033847
UniProt	Q9UP65	Q08EC7
RefSeq (mRNA)	NM_001159322	NM_001004762
RefSeq (protein)	NP_001152794	NP_001004762
Location (UCSC)	Chr 19: 48.05 – 48.11 Mb	Chr 7: 13.32 – 13.36 Mb
PubMed search

Cytosolic phospholipase A2 gamma is an enzyme that in humans is encoded by the PLA2G4C gene.^[1][2]

References

1. Underwood KW, Song C, Kriz RW, Chang XJ, Knopf JL, Lin LL (Sep 1998). "A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2". J Biol Chem 273 (34): 21926–32. doi:10.1074/jbc.273.34.21926. PMID 9705332.
2. "Entrez Gene: PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)".

Further reading

• Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology 19 (4–5): 683–8. PMID 9745929.
• Wu T, Angus CW, Yao XL, et al. (1997). "P11, a unique member of the S100 family of calcium-binding proteins, interacts with and inhibits the activity of the 85-kDa cytosolic phospholipase A2". J. Biol. Chem. 272 (27): 17145–53. doi:10.1074/jbc.272.27.17145. PMID 9202034.
• Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.
• Pickard RT, Strifler BA, Kramer RM, Sharp JD (1999). "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2". J. Biol. Chem. 274 (13): 8823–31. doi:10.1074/jbc.274.13.8823. PMID 10085124.
• Smith JS, Tachibana I, Pohl U, et al. (2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics 64 (1): 44–50. doi:10.1006/geno.1999.6101. PMID 10708517.
• Hartmann C, Johnk L, Sasaki H, et al. (2002). "Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q loss in human gliomas". Brain Pathol. 12 (2): 178–82. doi:10.1111/j.1750-3639.2002.tb00432.x. PMID 11958371.
• Stewart A, Ghosh M, Spencer DM, Leslie CC (2002). "Enzymatic properties of human cytosolic phospholipase A(2)gamma". J. Biol. Chem. 277 (33): 29526–36. doi:10.1074/jbc.M204856200. PMID 12039969.
• Lindbom J, Ljungman AG, Lindahl M, Tagesson C (2003). "Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma". J. Interferon Cytokine Res. 22 (9): 947–55. doi:10.1089/10799900260286650. PMID 12396716.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Asai K, Hirabayashi T, Houjou T, et al. (2003). "Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress". J. Biol. Chem. 278 (10): 8809–14. doi:10.1074/jbc.M212117200. PMID 12502717.
• Jenkins CM, Han X, Yang J, et al. (2004). "Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis". Biochemistry 42 (40): 11798–807. doi:10.1021/bi034611q. PMID 14529291.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dong M, Johnson M, Rezaie A, et al. (2005). "Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis". Clin. Cancer Res. 11 (6): 2265–71. doi:10.1158/1078-0432.CCR-04-1079. PMID 15788676.
• Yan W, Jenkins CM, Han X, et al. (2005). "The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling". J. Biol. Chem. 280 (29): 26669–79. doi:10.1074/jbc.M502358200. PMID 15908428.
• Yamashita A, Kamata R, Kawagishi N, et al. (2005). "Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)". J. Biochem. 137 (5): 557–67. doi:10.1093/jb/mvi067. PMID 15944408.
• Zhao X, Wang D, Zhao Z, et al. (2006). "Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells". J. Biol. Chem. 281 (39): 29357–68. doi:10.1074/jbc.M513105200. PMID 16882668.