PLA2R1

Phospholipase A2 receptor 1, 180kDa
Identifiers
Symbols	PLA2R1 ; CLEC13C; PLA2-R; PLA2G1R; PLA2IR; PLA2R
External IDs	OMIM: 604939 MGI: 102468 HomoloGene: 32016 GeneCards: PLA2R1 Gene
Gene ontology Molecular function • receptor activity • carbohydrate binding • phospholipase binding Cellular component • extracellular region • plasma membrane • integral component of plasma membrane • cell surface • integral component of membrane • receptor complex • extracellular exosome Biological process • cytokine production • endocytosis • receptor-mediated endocytosis • positive regulation of DNA damage response, signal transduction by p53 class mediator • reactive oxygen species metabolic process • positive regulation of arachidonic acid secretion • replicative senescence • oxidative stress-induced premature senescence • negative regulation of phospholipase A2 activity • negative regulation of arachidonic acid secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22925	18779
Ensembl	ENSG00000153246	ENSMUSG00000102781
UniProt	Q13018	Q62028
RefSeq (mRNA)	NM_001007267	NM_008867
RefSeq (protein)	NP_001007268	NP_032893
Location (UCSC)	Chr 2: 159.93 – 160.06 Mb	Chr 2: 60.42 – 60.55 Mb
PubMed search

Secretory phospholipase A2 receptor is an enzyme that in humans is encoded by the PLA2R1 gene.^[1][2][3]

Clinical significance

M-type phospholipase A2 receptor is the major antigen in idiopathic membranous nephropathy attributed to over 70% of cases.^[4]

References

1. Ancian P, Lambeau G, Mattéi MG, Lazdunski M (Apr 1995). "The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization". The Journal of Biological Chemistry 270 (15): 8963–70. doi:10.1074/jbc.270.15.8963. PMID 7721806.
2. Higashino K, Ishizaki J, Kishino J, Ohara O, Arita H (Oct 1994). "Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals". European Journal of Biochemistry / FEBS 225 (1): 375–82. doi:10.1111/j.1432-1033.1994.00375.x. PMID 7925459.
3. "Entrez Gene: PLA2R1 phospholipase A2 receptor 1, 180kDa".
4. Beck LH, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ (Jul 2009). "M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy". The New England Journal of Medicine 361 (1): 11–21. doi:10.1056/NEJMoa0810457. PMC 2762083. PMID 19571279.

Further reading

• Silliman CC, Moore EE, Zallen G, Gonzalez R, Johnson JL, Elzi DJ, Meng X, Hanasaki K, Ishizaki J, Arita H, Ao L, England KM, Banerjee A (Oct 2002). "Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion". American Journal of Physiology. Cell Physiology 283 (4): C1102–13. doi:10.1152/ajpcell.00608.2001. PMID 12225974.
• Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Molecular Vision 8: 196–204. PMID 12107411.
• Morioka Y, Saiga A, Yokota Y, Suzuki N, Ikeda M, Ono T, Nakano K, Fujii N, Ishizaki J, Arita H, Hanasaki K (Sep 2000). "Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor". Archives of Biochemistry and Biophysics 381 (1): 31–42. doi:10.1006/abbi.2000.1977. PMID 11019817.
• Yokota Y, Higashino K, Nakano K, Arita H, Hanasaki K (Jul 2000). "Identification of group X secretory phospholipase A(2) as a natural ligand for mouse phospholipase A(2) receptor". FEBS Letters 478 (1-2): 187–91. doi:10.1016/S0014-5793(00)01848-2. PMID 10922494.
• Yokota Y, Ikeda M, Higashino K, Nakano K, Fujii N, Arita H, Hanasaki K (Jul 2000). "Enhanced tissue expression and elevated circulating level of phospholipase A(2) receptor during murine endotoxic shock". Archives of Biochemistry and Biophysics 379 (1): 7–17. doi:10.1006/abbi.2000.1849. PMID 10864436.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.