PLEK2
| Pleckstrin 2 | |||||||||||||
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PDB rendering based on 1v3f. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbol | PLEK2 | ||||||||||||
| External IDs | OMIM: 608007 MGI: 1351466 HomoloGene: 8447 GeneCards: PLEK2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 26499 | 27260 | |||||||||||
| Ensembl | ENSG00000100558 | ENSMUSG00000021118 | |||||||||||
| UniProt | Q9NYT0 | Q9WV52 | |||||||||||
| RefSeq (mRNA) | NM_016445 | NM_013738 | |||||||||||
| RefSeq (protein) | NP_057529 | NP_038766 | |||||||||||
| Location (UCSC) |
Chr 14: 67.39 – 67.41 Mb |
Chr 12: 78.89 – 78.91 Mb | |||||||||||
| PubMed search | |||||||||||||
Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene.[1][2][3] The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.[4]
References
- ↑ Lemmon MA, Ferguson KM, Abrams CS (Mar 2002). "Pleckstrin homology domains and the cytoskeleton". FEBS Lett 513 (1): 71–6. doi:10.1016/S0014-5793(01)03243-4. PMID 11911883.
- ↑ Hamaguchi N, Ihara S, Ohdaira T, Nagano H, Iwamatsu A, Tachikawa H, Fukui Y (Aug 2007). "Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading". Biochem Biophys Res Commun 361 (2): 270–5. doi:10.1016/j.bbrc.2007.06.132. PMID 17658464.
- ↑ "Entrez Gene: PLEK2 pleckstrin 2".
- ↑ "AceView: PLEK2 gene". AceView. National Library of Medicine. Retrieved 24 April 2011.
Further reading
- Bach TL, Kerr WT, Wang Y, et al. (2007). "PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.". Blood 109 (3): 1147–55. doi:10.1182/blood-2006-02-001339. PMC 1785144. PMID 17008542.
- Inazu T, Kuroiwa A, Matsuda Y, Miyamoto K (2005). "Cloning, expression and chromosomal assignment of human pleckstrin 2.". Mol. Biol. Rep. 32 (1): 35–40. doi:10.1007/s11033-004-4747-x. PMID 15865208.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Inazu T, Yamada K, Miyamoto K (1999). "Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family.". Biochem. Biophys. Res. Commun. 265 (1): 87–93. doi:10.1006/bbrc.1999.1461. PMID 10548495.
- Hu MH, Bauman EM, Roll RL, et al. (1999). "Pleckstrin 2, a widely expressed paralog of pleckstrin involved in actin rearrangement.". J. Biol. Chem. 274 (31): 21515–8. doi:10.1074/jbc.274.31.21515. PMID 10419454.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
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