PLSCR4

Phospholipid scramblase 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3Q5U​
Identifiers
Symbols	PLSCR4 ; TRA1
External IDs	OMIM: 607612 MGI: 2143267 HomoloGene: 23217 GeneCards: PLSCR4 Gene
Gene ontology Molecular function • calcium ion binding • protein binding • SH3 domain binding • phospholipid scramblase activity • enzyme binding • CD4 receptor binding Cellular component • plasma membrane • integral component of membrane • extracellular exosome Biological process • phospholipid scrambling • cellular response to lipopolysaccharide Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57088	235527
Ensembl	ENSG00000114698	ENSMUSG00000032377
UniProt	Q9NRQ2	P58196
RefSeq (mRNA)	NM_001128304	NM_178711
RefSeq (protein)	NP_001121776	NP_848826
Location (UCSC)	Chr 3: 146.19 – 146.25 Mb	Chr 9: 92.46 – 92.49 Mb
PubMed search

Phospholipid scramblase 4, also known as Ca²⁺-dependent phospholipid scramblase 4, is a protein that in humans is encoded by the PLSCR4 gene.^[1][2]

See also

• scramblase

References

1. "Entrez Gene: phospholipid scramblase 4".
2. Wiedmer T, Zhou Q, Kwoh DY, Sims PJ (July 2000). "Identification of three new members of the phospholipid scramblase gene family". Biochim. Biophys. Acta 1467 (1): 244–53. doi:10.1016/S0005-2736(00)00236-4. PMID 10930526.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Rose JE, Behm FM, Drgon T, et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.". Mol. Med. 16 (7-8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shibata H, Suzuki H, Kakiuchi T, et al. (2008). "Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants.". J. Biol. Chem. 283 (15): 9623–32. doi:10.1074/jbc.M800717200. PMID 18256029.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sahu SK, Aradhyam GK, Gummadi SN (2009). "Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell.". Biochim. Biophys. Acta 1790 (10): 1274–81. doi:10.1016/j.bbagen.2009.06.008. PMID 19540310.
• Py B, Basmaciogullari S, Bouchet J, et al. (2009). "The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane.". PLoS ONE 4 (3): e5006. doi:10.1371/journal.pone.0005006. PMC 2659420. PMID 19333378.