PLXNA2

Plexin A2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3Q3J​
Identifiers
Symbols	PLXNA2 ; OCT; PLXN2
External IDs	OMIM: 601054 MGI: 107684 HomoloGene: 56427 GeneCards: PLXNA2 Gene
Gene ontology Molecular function • protein binding • semaphorin receptor activity Cellular component • semaphorin receptor complex • plasma membrane • integral component of plasma membrane Biological process • somitogenesis • axon guidance • neural tube development • cerebellar granule cell precursor tangential migration • regulation of cell migration • centrosome localization • pharyngeal system development • limb bud formation • semaphorin-plexin signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5362	18845
Ensembl	ENSG00000076356	ENSMUSG00000026640
UniProt	O75051	P70207
RefSeq (mRNA)	NM_025179	NM_008882
RefSeq (protein)	NP_079455	NP_032908
Location (UCSC)	Chr 1: 208.02 – 208.24 Mb	Chr 1: 194.62 – 194.82 Mb
PubMed search

Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.^[1][2]

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.^[2]

In some studies, the PLXNA2 gene is associated with schizophrenia.^[3] and anxiety.^[4]

References

1. Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci USA 93 (2): 674–8. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614.
2. "Entrez Gene: PLXNA2 plexin A2".
3. Gene Overview of All Published Schizophrenia-Association Studies for PLXNA2 - база данных SZGene, сайт Schizophrenia Research Forum
4. Wray NR, James MR, Mah SP, Nelson M, Andrews G, Sullivan PF, Montgomery GW, Birley AJ, Braun A, Martin NG (March 2007). "Anxiety and comorbid measures associated with PLXNA2". Arch. Gen. Psychiatry 64 (3): 318–26. doi:10.1001/archpsyc.64.3.318. PMID 17339520.

Further reading

• Negishi M, Oinuma I, Katoh H (2005). "Plexins: axon guidance and signal transduction". Cell. Mol. Life Sci. 62 (12): 1363–71. doi:10.1007/s00018-005-5018-2. PMID 15818466.
• Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mah S, Nelson MR, Delisi LE, et al. (2006). "Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia". Mol. Psychiatry 11 (5): 471–8. doi:10.1038/sj.mp.4001785. PMID 16402134.
• Fujii T, Iijima Y, Kondo H, et al. (2007). "Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population". Prog. Neuropsychopharmacol. Biol. Psychiatry 31 (4): 873–7. doi:10.1016/j.pnpbp.2007.01.027. PMID 17346868.