PLXNB2

Plexin B2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4E71​
Identifiers
Symbols	PLXNB2 ; MM1; Nbla00445; PLEXB2; dJ402G11.3
External IDs	OMIM: 604293 MGI: 2154239 HomoloGene: 66630 GeneCards: PLXNB2 Gene
Gene ontology Molecular function • protein binding • semaphorin receptor activity Cellular component • integral component of plasma membrane • cell surface • extracellular exosome Biological process • neural tube closure • regulation of protein phosphorylation • neuroblast proliferation • brain development • regulation of cell shape • regulation of GTPase activity • positive regulation of axonogenesis • semaphorin-plexin signaling pathway • regulation of neuron migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23654	140570
Ensembl	ENSG00000196576	ENSMUSG00000036606
UniProt	O15031	B2RXS4
RefSeq (mRNA)	NM_012401	NM_001159521
RefSeq (protein)	NP_036533	NP_001152993
Location (UCSC)	Chr 22: 50.27 – 50.31 Mb	Chr 15: 89.16 – 89.17 Mb
PubMed search

Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.^[1][2][3]

Function

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)).[supplied by OMIM]^[3]

Interactions

PLXNB2 has been shown to interact with ARHGEF11.^[2][4]

References

1. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (Oct 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
2. Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J Biol Chem 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
3. "Entrez Gene: PLXNB2 plexin B2".
4. Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.

Further reading

• Shinoura N, Shamraj OI, Hugenholz H, Zhu JG, McBlack P, Warnick R, Tew JJ, Wani MA, Menon AG (1995). "Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors". Cancer Lett. 89 (2): 215–21. doi:10.1016/0304-3835(95)03690-X. PMID 7889532.
• Trofatter JA, Long KR, Murrell JR, Stotler CJ, Gusella JF, Buckler AJ (1996). "An expression-independent catalog of genes from human chromosome 22". Genome Res. 5 (3): 214–24. doi:10.1101/gr.5.3.214. PMID 8593609.
• Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L (2003). "Functional regulation of semaphorin receptors by proprotein convertases". J. Biol. Chem. 278 (12): 10094–101. doi:10.1074/jbc.M210156200. PMID 12533544.
• Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene 23 (30): 5131–7. doi:10.1038/sj.onc.1207650. PMID 15184888.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.