PLXND1

Plexin D1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3H6N​
Identifiers
Symbols	PLXND1 ; PLEXD1
External IDs	OMIM: 604282 MGI: 2154244 HomoloGene: 22866 GeneCards: PLXND1 Gene
Gene ontology Molecular function • protein binding • semaphorin receptor activity • protein domain specific binding Cellular component • plasma membrane • integral component of plasma membrane • lamellipodium Biological process • angiogenesis • patterning of blood vessels • outflow tract morphogenesis • axon guidance • synapse assembly • regulation of cell migration • positive regulation of protein binding • endothelial cell migration • regulation of angiogenesis • dichotomous subdivision of terminal units involved in salivary gland branching • semaphorin-plexin signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23129	67784
Ensembl	ENSG00000004399	ENSMUSG00000030123
UniProt	Q9Y4D7	Q3UH93
RefSeq (mRNA)	NM_015103	NM_026376
RefSeq (protein)	NP_055918	NP_080652
Location (UCSC)	Chr 3: 129.56 – 129.61 Mb	Chr 6: 115.95 – 116 Mb
PubMed search

Plexin-D1 is a protein that in humans is encoded by the PLXND1 gene.^[1][2]

References

1. van der Zwaag B, Hellemons AJ, Leenders WP, Burbach JP, Brunner HG, Padberg GW, Van Bokhoven H (Nov 2002). "PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis". Dev Dyn 225 (3): 336–43. doi:10.1002/dvdy.10159. PMID 12412018.
2. "Entrez Gene: PLXND1 plexin D1".

Further reading

• Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.". Cell 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gitler AD, Lu MM, Epstein JA (2004). "PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.". Dev. Cell 7 (1): 107–16. doi:10.1016/j.devcel.2004.06.002. PMID 15239958.
• van der Zwaag B, Verzijl HT, Wichers KH, et al. (2004). "Sequence analysis of the PLEXIN-D1 gene in Möbius syndrome patients.". Pediatr. Neurol. 31 (2): 114–8. doi:10.1016/j.pediatrneurol.2004.02.004. PMID 15301830.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.