PNPLA8

Patatin-like phospholipase domain containing 8
Identifiers
Symbols	PNPLA8 ; IPLA2-2; IPLA2G; MMLA; PNPLA-gamma; iPLA2gamma
External IDs	OMIM: 612123 MGI: 1914702 HomoloGene: 12136 GeneCards: PNPLA8 Gene
EC number	3.1.1.5
Gene ontology Molecular function • lysophospholipase activity • ATP binding • calcium-independent phospholipase A2 activity Cellular component • Golgi membrane • intracellular • peroxisome • peroxisomal membrane • endoplasmic reticulum membrane • membrane • integral component of membrane • perinuclear region of cytoplasm Biological process • prostaglandin biosynthetic process • fatty acid metabolic process • phospholipid metabolic process • cell death • arachidonic acid metabolic process • phosphatidylcholine catabolic process • phosphatidylcholine acyl-chain remodeling • phosphatidylethanolamine acyl-chain remodeling • linoleic acid metabolic process • small molecule metabolic process • phosphatidylethanolamine catabolic process • glycerophospholipid biosynthetic process • arachidonic acid secretion Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50640	67452
Ensembl	ENSG00000135241	ENSMUSG00000036257
UniProt	Q9NP80	Q8K1N1
RefSeq (mRNA)	NM_001256007	NM_026164
RefSeq (protein)	NP_001242936	NP_080440
Location (UCSC)	Chr 7: 108.47 – 108.57 Mb	Chr 12: 44.22 – 44.31 Mb
PubMed search

Calcium-independent phospholipase A2-gamma is an enzyme that in humans is encoded by the PNPLA8 gene.^{[1][2][3][4][5]}

References

1. Mancuso DJ, Jenkins CM, Gross RW (May 2000). "The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2)". J Biol Chem 275 (14): 9937–45. doi:10.1074/jbc.275.14.9937. PMID 10744668.
2. Tanaka H, Takeya R, Sumimoto H (Jul 2000). "A novel intracellular membrane-bound calcium-independent phospholipase A(2)". Biochem Biophys Res Commun 272 (2): 320–6. doi:10.1006/bbrc.2000.2776. PMID 10833412.
3. Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family". J Lipid Res 47 (9): 1940–9. doi:10.1194/jlr.M600185-JLR200. PMID 16799181.
4. Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". J Lipid Res. 50 Suppl (Supplement): S63–8. doi:10.1194/jlr.R800082-JLR200. PMC 2674697. PMID 19029121.
5. "Entrez Gene: PNPLA8 patatin-like phospholipase domain containing 8".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Wiemann S, Arlt D, Huber W (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Murakami M, Masuda S, Ueda-Semmyo K (2005). "Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2". J. Biol. Chem. 280 (14): 14028–41. doi:10.1074/jbc.M413766200. PMID 15695510.
• Mehrle A, Rosenfelder H, Schupp I (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.