POLDIP2
| Polymerase (DNA-directed), delta interacting protein 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | POLDIP2 ; PDIP38; POLD4; p38 | ||||||||||||
| External IDs | OMIM: 611519 MGI: 1915061 HomoloGene: 9201 GeneCards: POLDIP2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 26073 | 67811 | |||||||||||
| Ensembl | ENSG00000004142 | ENSMUSG00000001100 | |||||||||||
| UniProt | Q9Y2S7 | Q91VA6 | |||||||||||
| RefSeq (mRNA) | NM_001290145 | NM_026389 | |||||||||||
| RefSeq (protein) | NP_001277074 | NP_080665 | |||||||||||
| Location (UCSC) |
Chr 17: 28.35 – 28.36 Mb |
Chr 11: 78.51 – 78.52 Mb | |||||||||||
| PubMed search | |||||||||||||
Polymerase delta-interacting protein 2 is an enzyme that in humans is encoded by the POLDIP2 gene.[1][2]
This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. The encoded protein also interacts with proliferating cell nuclear antigen. Some transcripts of this gene overlap in a tail-to-tail orientation with the gene for tumor necrosis factor, alpha-induced protein 1 (TNFAIP1).[2]
Interactions
POLDIP2 has been shown to interact with PCNA.[1]
References
- 1 2 Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J Biol Chem 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
- 1 2 "Entrez Gene: POLDIP2 polymerase (DNA-directed), delta interacting protein 2".
Further reading
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Xie B, Li H, Wang Q, et al. (2005). "Further characterization of human DNA polymerase delta interacting protein 38". J. Biol. Chem. 280 (23): 22375–84. doi:10.1074/jbc.M414597200. PMID 15811854.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Klaile E, Müller MM, Kannicht C, et al. (2007). "The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38". J. Biol. Chem. 282 (36): 26629–40. doi:10.1074/jbc.M701807200. PMID 17623671.
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