POLDIP3

Polymerase (DNA-directed), delta interacting protein 3
Identifiers
Symbols	POLDIP3 ; PDIP46; SKAR
External IDs	OMIM: 611520 MGI: 1921076 HomoloGene: 13007 GeneCards: POLDIP3 Gene
Gene ontology Molecular function • nucleotide binding • protein binding • poly(A) RNA binding Cellular component • transcription export complex • nucleoplasm • cytoplasm • nuclear speck • exon-exon junction complex • intracellular membrane-bounded organelle Biological process • poly(A)+ mRNA export from nucleus • positive regulation of translation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84271	73826
Ensembl	ENSG00000100227	ENSMUSG00000041815
UniProt	Q9BY77	Q8BG81
RefSeq (mRNA)	NM_001278657	NM_178627
RefSeq (protein)	NP_001265586	NP_848742
Location (UCSC)	Chr 22: 42.58 – 42.61 Mb	Chr 15: 83.13 – 83.15 Mb
PubMed search

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.^[1][2]

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.^[2]

Interactions

POLDIP3 has been shown to interact with P70-S6 Kinase 1.^[3]

References

1. Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J Biol Chem 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
2. "Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3".
3. Richardson, Celeste J; Bröenstrup Mark; Fingar Diane C; Jülich Kristina; Ballif Bryan A; Gygi Steven; Blenis John (Sep 2004). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. (England) 14 (17): 1540–9. doi:10.1016/j.cub.2004.08.061. ISSN 0960-9822. PMID 15341740.

Further reading

• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22.". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
• Richardson CJ, Bröenstrup M, Fingar DC, et al. (2005). "SKAR is a specific target of S6 kinase 1 in cell growth control.". Curr. Biol. 14 (17): 1540–9. doi:10.1016/j.cub.2004.08.061. PMID 15341740.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Smyk A, Szuminska M, Uniewicz KA, et al. (2006). "Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth.". FEBS J. 273 (20): 4728–41. doi:10.1111/j.1742-4658.2006.05477.x. PMID 16984396.