POLG2

Polymerase (DNA directed), gamma 2, accessory subunit
PDB rendering based on 2g4c.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2G4C​, 3IKL​, 3IKM​
Identifiers
Symbols	POLG2 ; HP55; MTPOLB; PEOA4; POLB; POLG-BETA; POLGB
External IDs	OMIM: 604983 MGI: 1354947 HomoloGene: 5221 GeneCards: POLG2 Gene
EC number	2.7.7.7
Gene ontology Molecular function • DNA binding • DNA-directed DNA polymerase activity • protein binding • identical protein binding Cellular component • mitochondrial chromosome • mitochondrial matrix • mitochondrial nucleoid • extracellular exosome Biological process • in utero embryonic development • DNA replication • DNA-dependent DNA replication • mitochondrial DNA replication • DNA repair • organelle organization • mitochondrion organization • respiratory electron transport chain • mitochondrion morphogenesis • DNA biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11232	50776
Ensembl	ENSG00000256525	ENSMUSG00000020718
UniProt	Q9UHN1	Q9QZM2
RefSeq (mRNA)	NM_007215	NM_015810
RefSeq (protein)	NP_009146	NP_056625
Location (UCSC)	Chr 17: 64.48 – 64.5 Mb	Chr 11: 106.77 – 106.78 Mb
PubMed search

DNA polymerase subunit gamma-2, mitochondrial is an protein that in humans is encoded by the POLG2 gene. The POLG2 gene encodes a 55 kDa accessory subunit protein that imparts high processivity and salt tolerance to the catalytic subunit of DNA polymerase gamma, encoded by the POLG gene. ^[1][2][3]

References

1. Wang Y, Farr CL, Kaguni LS (Jul 1997). "Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme". J Biol Chem 272 (21): 13640–6. doi:10.1074/jbc.272.21.13640. PMID 9153213.
2. "Entrez Gene: POLG2 polymerase (DNA directed), gamma 2, accessory subunit".
3. Lim SE, Longley MJ, Copeland WC (1999). "The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance". J. Biol. Chem. 274 (53): 38197–203. doi:10.1074/jbc.274.53.38197. PMID 10608893.

Further reading

• Michiels S, Danoy P, Dessen P, et al. (2007). "Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers.". Carcinogenesis 28 (8): 1731–9. doi:10.1093/carcin/bgm111. PMID 17494052.
• Huang H, Shiffman ML, Cheung RC, et al. (2006). "Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C.". Gastroenterology 130 (6): 1679–87. doi:10.1053/j.gastro.2006.02.032. PMID 16697732.
• Longley MJ, Clark S, Yu Wai Man C, et al. (2006). "Mutant POLG2 Disrupts DNA Polymerase γ Subunits and Causes Progressive External Ophthalmoplegia". Am. J. Hum. Genet. 78 (6): 1026–34. doi:10.1086/504303. PMC 1474082. PMID 16685652.
• Yakubovskaya E, Chen Z, Carrodeguas JA, et al. (2006). "Functional human mitochondrial DNA polymerase gamma forms a heterotrimer". J. Biol. Chem. 281 (1): 374–82. doi:10.1074/jbc.M509730200. PMID 16263719.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Carrodeguas JA, Pinz KG, Bogenhagen DF (2003). "DNA binding properties of human pol gammaB". J. Biol. Chem. 277 (51): 50008–14. doi:10.1074/jbc.M207030200. PMID 12379656.
• Johnson AA, Tsai Y, Graves SW, Johnson KA (2000). "Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization". Biochemistry 39 (7): 1702–8. doi:10.1021/bi992104w. PMID 10677218.
• Carrodeguas JA, Bogenhagen DF (2000). "Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase". Nucleic Acids Res. 28 (5): 1237–44. doi:10.1093/nar/28.5.1237. PMC 102604. PMID 10666468.
• Lim SE, Longley MJ, Copeland WC (1999). "The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance". J. Biol. Chem. 274 (53): 38197–203. doi:10.1074/jbc.274.53.38197. PMID 10608893.