POLR1D

Polymerase (RNA) I polypeptide D, 16kDa
Identifiers
Symbols	POLR1D ; AC19; POLR1C; RPA16; RPA9; RPAC2; RPC16; RPO1-3; TCS2
External IDs	OMIM: 613715 MGI: 108403 HomoloGene: 22239 GeneCards: POLR1D Gene
Gene ontology Molecular function • RNA polymerase I activity • RNA polymerase III activity • DNA binding • protein binding • protein dimerization activity Cellular component • nucleoplasm • DNA-directed RNA polymerase III complex • DNA-directed RNA polymerase I complex • cytosol Biological process • transcription from RNA polymerase I promoter • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase I promoter • termination of RNA polymerase I transcription • transcription from RNA polymerase III promoter • transcription elongation from RNA polymerase III promoter • termination of RNA polymerase III transcription • gene expression • positive regulation of type I interferon production • regulation of gene expression, epigenetic • innate immune response • negative regulation of gene expression, epigenetic Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51082	20018
Ensembl	ENSG00000186184	ENSMUSG00000029642
UniProt	Q9Y2S0	P97304
RefSeq (mRNA)	NM_001206559	NM_009087
RefSeq (protein)	NP_001193488	NP_033113
Location (UCSC)	Chr 13: 27.62 – 27.67 Mb	Chr 5: 147.08 – 147.11 Mb
PubMed search

DNA-directed RNA polymerases I and III subunit RPAC2 is a protein that in humans is encoded by the POLR1D gene.^[1][2][3]

Interactions

POLR1D has been shown to interact with POLR1C.^[4][5]

References

1. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
2. Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Nov 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits". Molecular and Cellular Biology 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
3. "Entrez Gene: POLR1D polymerase (RNA) I polypeptide D, 16kDa".
4. Yao Y, Yamamoto K, Nishi Y, Nogi Y, Muramatsu M (Dec 1996). "Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III". The Journal of Biological Chemistry 271 (51): 32881–5. doi:10.1074/jbc.271.51.32881. PMID 8955128.
5. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Yao Y, Yamamoto K, Nishi Y, Nogi Y, Muramatsu M (Dec 1996). "Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III". The Journal of Biological Chemistry 271 (51): 32881–5. doi:10.1074/jbc.271.51.32881. PMID 8955128.
• Dundr M, Hoffmann-Rohrer U, Hu Q, Grummt I, Rothblum LI, Phair RD, Misteli T (Nov 2002). "A kinetic framework for a mammalian RNA polymerase in vivo". Science 298 (5598): 1623–6. doi:10.1126/science.1076164. PMID 12446911.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jul 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Molecular and Cellular Biology 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.