POLR3C

Polymerase (RNA) III (DNA directed) polypeptide C (62kD)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2XUB​, 2XV4​
Identifiers
Symbols	POLR3C ; RPC3; RPC62
External IDs	MGI: 1921664 HomoloGene: 38185 GeneCards: POLR3C Gene
Gene ontology Molecular function • RNA polymerase III activity • DNA binding • DNA-directed RNA polymerase activity • protein binding Cellular component • nucleus • nucleoplasm • DNA-directed RNA polymerase III complex • cytosol Biological process • regulation of transcription from RNA polymerase III promoter • transcription from RNA polymerase III promoter • transcription elongation from RNA polymerase III promoter • termination of RNA polymerase III transcription • gene expression • positive regulation of type I interferon production • positive regulation of interferon-beta production • innate immune response • positive regulation of innate immune response • defense response to virus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10623	74414
Ensembl	ENSG00000186141	ENSMUSG00000028099
UniProt	Q9BUI4	Q9D483
RefSeq (mRNA)	NM_001303456	NM_028925
RefSeq (protein)	NP_001290385	NP_083201
Location (UCSC)	Chr 1: 145.82 – 145.84 Mb	Chr 3: 96.71 – 96.73 Mb
PubMed search

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene.^[1][2][3]

Interactions

POLR3C has been shown to interact with GTF3C4.^[4][5]

Related gene problems

• TAR syndrome^[6]
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

References

1. Wang Z, Roeder RG (Jun 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes Dev 11 (10): 1315–26. doi:10.1101/gad.11.10.1315. PMID 9171375.
2. Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Oct 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits". Mol Cell Biol 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
3. "Entrez Gene: POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)".
4. Hsieh, Y J; Wang Z; Kovelman R; Roeder R G (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. (UNITED STATES) 19 (7): 4944–52. ISSN 0270-7306. PMC 84305. PMID 10373544.
5. Hsieh, Y J; Kundu T K; Wang Z; Kovelman R; Roeder R G (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7697–704. ISSN 0270-7306. PMC 84812. PMID 10523658.
6. Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

Further reading

• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC.". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hsieh YJ, Wang Z, Kovelman R, Roeder RG (1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III.". Mol. Cell. Biol. 19 (7): 4944–52. PMC 84305. PMID 10373544.
• Hsieh YJ, Kundu TK, Wang Z, et al. (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity.". Mol. Cell. Biol. 19 (11): 7697–704. PMC 84812. PMID 10523658.
• Kuwana M, Kimura K, Kawakami Y (2002). "Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay.". Arthritis Rheum. 46 (10): 2742–7. doi:10.1002/art.10521. PMID 12384934.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.