POLR3D

Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
Identifiers
Symbols	POLR3D ; BN51T; RPC4; RPC53; TSBN51
External IDs	OMIM: 187280 MGI: 1914315 HomoloGene: 1303 ChEMBL: 2947 GeneCards: POLR3D Gene
EC number	2.7.7.6
Gene ontology Molecular function • RNA polymerase III activity • DNA binding • chromatin binding Cellular component • nuclear chromatin • nucleoplasm • DNA-directed RNA polymerase III complex • cytoplasm • cytosol Biological process • transcription from RNA polymerase III promoter • transcription elongation from RNA polymerase III promoter • termination of RNA polymerase III transcription • gene expression • positive regulation of type I interferon production • positive regulation of interferon-beta production • innate immune response • positive regulation of innate immune response • defense response to virus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	661	67065
Ensembl	ENSG00000168495	ENSMUSG00000000776
UniProt	P05423	Q91WD1
RefSeq (mRNA)	NM_001722	NM_001164082
RefSeq (protein)	NP_001713	NP_001157554
Location (UCSC)	Chr 8: 22.25 – 22.25 Mb	Chr 14: 70.44 – 70.44 Mb
PubMed search

DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene.^[1][2][3]

This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures.^[3]

Interactions

POLR3D has been shown to interact with POLR3E.^[1]

References

1. Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Oct 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits". Mol Cell Biol 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
2. Chong SS, Hu P, Hernandez N (Jun 2001). "Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex". J Biol Chem 276 (23): 20727–34. doi:10.1074/jbc.M100088200. PMID 11279001.
3. "Entrez Gene: POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa".

Further reading

• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC.". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
• Greco A, Ittmann M, Barletta C, et al. (1989). "Chromosomal localization of human genes required for G1 progression in mammalian cells.". Genomics 4 (3): 240–5. doi:10.1016/0888-7543(89)90326-1. PMID 2714790.
• Ittmann M, Greco A, Basilico C (1988). "Isolation of the human gene that complements a temperature-sensitive cell cycle mutation in BHK cells.". Mol. Cell. Biol. 7 (10): 3386–93. PMC 367988. PMID 3683386.
• Jackson AJ, Ittmann M, Pugh BF (1995). "The BN51 protein is a polymerase (Pol)-specific subunit of RNA Pol III which reveals a link between Pol III transcription and pre-rRNA processing.". Mol. Cell. Biol. 15 (1): 94–101. PMC 231913. PMID 7799973.
• Ittmann MM (1994). "Cell cycle control of the BN51 cell cycle gene which encodes a subunit of RNA polymerase III.". Cell Growth Differ. 5 (7): 783–8. PMID 7947392.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.