POMP

Proteasome maturation protein
Identifiers
Symbols	POMP ; C13orf12; HSPC014; PNAS-110; UMP1
External IDs	OMIM: 613386 MGI: 1913787 HomoloGene: 41077 GeneCards: POMP Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • nucleoplasm • cytoplasm • endoplasmic reticulum • cytosol • organelle membrane Biological process • proteasome assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51371	66537
Ensembl	ENSG00000132963	ENSMUSG00000029649
UniProt	Q9Y244	Q9CQT5
RefSeq (mRNA)	NM_015932	NM_025624
RefSeq (protein)	NP_057016	NP_079900
Location (UCSC)	Chr 13: 28.66 – 28.68 Mb	Chr 5: 147.86 – 147.88 Mb
PubMed search

Proteasome maturation protein is a protein that in humans is encoded by the POMP gene.^[1][2] It is a short-lived maturation factor required for 20S proteasome subunit biogenesis.

References

1. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
2. "Entrez Gene: POMP proteasome maturation protein".

Further reading

• Griffin TA, Slack JP, McCluskey TS, et al. (2000). "Identification of proteassemblin, a mammalian homologue of the yeast protein, Ump1p, that is required for normal proteasome assembly.". Mol. Cell Biol. Res. Commun. 3 (4): 212–7. doi:10.1006/mcbr.2000.0213. PMID 10891394.
• Witt E, Zantopf D, Schmidt M, et al. (2000). "Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomes.". J. Mol. Biol. 301 (1): 1–9. doi:10.1006/jmbi.2000.3959. PMID 10926487.
• Burri L, Höckendorff J, Boehm U, et al. (2000). "Identification and characterization of a mammalian protein interacting with 20S proteasome precursors.". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10348–53. doi:10.1073/pnas.190268597. PMC 27027. PMID 10973495.
• Tian S, Liu W, Wu Y, et al. (2002). "Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit.". Am. J. Physiol. Renal Physiol. 283 (1): F142–9. doi:10.1152/ajprenal.00258.2001. PMID 12060596.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jayarapu K, Griffin TA (2004). "Protein-protein interactions among human 20S proteasome subunits and proteassemblin.". Biochem. Biophys. Res. Commun. 314 (2): 523–8. doi:10.1016/j.bbrc.2003.12.119. PMID 14733938.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Heink S, Ludwig D, Kloetzel PM, Krüger E (2005). "IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response.". Proc. Natl. Acad. Sci. U.S.A. 102 (26): 9241–6. doi:10.1073/pnas.0501711102. PMC 1166598. PMID 15944226.
• Hirano Y, Hendil KB, Yashiroda H, et al. (2005). "A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.". Nature 437 (7063): 1381–5. doi:10.1038/nature04106. PMID 16251969.
• Hoefer MM, Boneberg EM, Grotegut S, et al. (2006). "Possible tetramerisation of the proteasome maturation factor POMP/proteassemblin/hUmp1 and its subcellular localisation.". Int. J. Biol. Macromol. 38 (3-5): 259–67. doi:10.1016/j.ijbiomac.2006.03.015. PMID 16624403.