PPIL4
| Peptidylprolyl isomerase (cyclophilin)-like 4 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PPIL4 ; HDCME13P | ||||||||||||
| External IDs | OMIM: 607609 MGI: 1914668 HomoloGene: 12126 GeneCards: PPIL4 Gene | ||||||||||||
| EC number | 5.2.1.8 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 85313 | 67418 | |||||||||||
| Ensembl | ENSG00000131013 | ENSMUSG00000015757 | |||||||||||
| UniProt | Q8WUA2 | Q9CXG3 | |||||||||||
| RefSeq (mRNA) | NM_139126 | NM_026141 | |||||||||||
| RefSeq (protein) | NP_624311 | NP_080417 | |||||||||||
| Location (UCSC) |
Chr 6: 149.5 – 149.55 Mb |
Chr 10: 7.79 – 7.82 Mb | |||||||||||
| PubMed search | |||||||||||||
Peptidyl-prolyl cis-trans isomerase-like 4 is an enzyme that in humans is encoded by the PPIL4 gene.[1]
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions.[1]
References
Further reading
- Zeng L, Zhou Z, Xu J, et al. (2002). "Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain.". Cytogenet. Cell Genet. 95 (1–2): 43–7. doi:10.1159/000057015. PMID 11978968.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. PMID 12747765.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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