PPM1F

Protein phosphatase, Mg2+/Mn2+ dependent, 1F
Identifiers
Symbols	PPM1F ; CAMKP; CaMKPase; FEM-2; POPX2; hFEM-2
External IDs	MGI: 1918464 HomoloGene: 22828 GeneCards: PPM1F Gene
EC number	3.1.3.16
Gene ontology Molecular function • protein serine/threonine phosphatase activity • protein binding • phosphatase activity • calmodulin-dependent protein phosphatase activity • metal ion binding Cellular component • cytosol • protein complex • perinuclear region of cytoplasm Biological process • negative regulation of protein kinase activity • positive regulation of gene expression • positive regulation of epithelial cell migration • positive regulation of cell-substrate adhesion • histone dephosphorylation • negative regulation of peptidyl-serine phosphorylation • cellular response to drug • peptidyl-threonine dephosphorylation • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of protein kinase activity by regulation of protein phosphorylation • negative regulation of transcription, DNA-templated • positive regulation of growth • positive regulation of chemotaxis • positive regulation of stress fiber assembly • positive regulation of focal adhesion assembly • intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9647	68606
Ensembl	ENSG00000100034	ENSMUSG00000026181
UniProt	P49593	Q8CGA0
RefSeq (mRNA)	NM_014634	NM_176833
RefSeq (protein)	NP_055449	NP_789803
Location (UCSC)	Chr 22: 21.92 – 21.95 Mb	Chr 16: 16.9 – 16.93 Mb
PubMed search

Protein phosphatase 1F is an enzyme that in humans is encoded by the PPM1F gene.^[1][2][3]

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.^[3]

References

1. Koh CG, Tan EJ, Manser E, Lim L (Feb 2002). "The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family". Curr Biol 12 (4): 317–21. doi:10.1016/S0960-9822(02)00652-8. PMID 11864573.
2. Tan KM, Chan SL, Tan KO, Yu VC (Nov 2001). "The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis". J Biol Chem 276 (47): 44193–202. doi:10.1074/jbc.M105880200. PMID 11559703.
3. "Entrez Gene: PPM1F protein phosphatase 1F (PP2C domain containing)".

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Kawasaki K, Minoshima S, Nakato E, et al. (1997). "One-megabase sequence analysis of the human immunoglobulin lambda gene locus". Genome Res. 7 (3): 250–61. doi:10.1101/gr.7.3.250. PMID 9074928.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
• Harvey BP, Banga SS, Ozer HL (2004). "Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts". J. Biol. Chem. 279 (23): 24889–98. doi:10.1074/jbc.M400656200. PMID 15140879.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.