PPP1R11
| Protein phosphatase 1, regulatory (inhibitor) subunit 11 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | PPP1R11 ; HCG-V; HCGV; IPP3; TCTE5; TCTEX5 | ||||||||||||
| External IDs | OMIM: 606670 MGI: 1923747 HomoloGene: 32520 GeneCards: PPP1R11 Gene | ||||||||||||
| EC number | 3.1.3.16 | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6992 | 76497 | |||||||||||
| Ensembl | ENSG00000204619 | ENSMUSG00000036398 | |||||||||||
| UniProt | O60927 | Q8K1L5 | |||||||||||
| RefSeq (mRNA) | NM_021959 | NM_029632 | |||||||||||
| RefSeq (protein) | NP_068778 | NP_083908 | |||||||||||
| Location (UCSC) |
Chr 6: 30.07 – 30.07 Mb |
Chr 17: 36.95 – 36.95 Mb | |||||||||||
| PubMed search | |||||||||||||
Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene.[1][2][3]
This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6.[3]
References
- ↑ Zhang J, Zhang L, Zhao S, Lee EY (Dec 1998). "Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1". Biochemistry 37 (47): 16728–34. doi:10.1021/bi981169g. PMID 9843442.
- ↑ Giffon T, Lepourcelet M, Pichon L, Jezequel P, Bouric P, Carn G, Pontarotti P, Gall JY, David V (Oct 1996). "Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region". Immunogenetics 44 (5): 331–9. doi:10.1007/BF02602777. PMID 8781118.
- 1 2 "Entrez Gene: PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11".
Further reading
- Amadou C, Ribouchon MT, Mattei MG, et al. (1995). "Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes". Genomics 26 (1): 9–20. doi:10.1016/0888-7543(95)80077-Y. PMID 7782091.
- el Kahloun A, Chauvel B, Mauvieux V, et al. (1993). "Localization of seven new genes around the HLA-A locus". Hum. Mol. Genet. 2 (1): 55–60. doi:10.1093/hmg/2.1.55. PMID 8490624.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Lepourcelet M, Andrieux N, Giffon T, et al. (1997). "Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence". Genomics 37 (3): 316–26. doi:10.1006/geno.1996.0566. PMID 8938444.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Lesage B, Beullens M, Pedelini L, et al. (2007). "A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3". Biochemistry 46 (31): 8909–19. doi:10.1021/bi7003119. PMID 17630778.
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