PPP1R12B

Protein phosphatase 1, regulatory subunit 12B
Identifiers
Symbols PPP1R12B ; MYPT2; PP1bp55
External IDs OMIM: 603768 MGI: 1916417 HomoloGene: 136757 ChEMBL: 2427 GeneCards: PPP1R12B Gene
EC number 3.1.3.53
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4660 329251
Ensembl ENSG00000077157 ENSMUSG00000073557
UniProt O60237 Q8BG95
RefSeq (mRNA) NM_001167857 NM_001081307
RefSeq (protein) NP_001161329 NP_001074776
Location (UCSC) Chr 1:
202.35 – 202.59 Mb
Chr 1:
134.75 – 134.96 Mb
PubMed search

Protein phosphatase 1 regulatory subunit 12B is an enzyme that in humans is encoded by the PPP1R12B gene.[1][2]

Myosin light chain phosphatase (MLCP) consists of three subunits- catalytic subunit, large subunit/myosin binding subunit (MBS) and small subunit (sm-M20). This gene is a multi-functional gene which encodes both MBS and sm-M20. MLCP regulates myosins and the dephosphorylation is enhanced by the presence of MBS. The sm-M20 is suggested to play a regulatory role in muscle contraction by binding to MBS. MBS is also encoded by another gene, myosin light chain phosphatase target subunit 1. sm-M20 shows higher binding affinity to this gene product than to myosin light chain phosphatase target subunit 2-MBS even though the two MBS proteins are highly similar. Although both MBSs increase the activity of MLCP, myosin light chain phosphatase target subunit 1-MBS is a more efficient activator. There are four alternatively spliced transcript variants described; two alter the MBS coding region and two alter the sm-M20 coding region of this gene.[2]

Interactions

PPP1R12B has been shown to interact with Interleukin 16.[3]

References

  1. Fujioka M, Takahashi N, Odai H, Araki S, Ichikawa K, Feng J, Nakamura M, Kaibuchi K, Hartshorne DJ, Nakano T, Ito M (Jun 1998). "A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping". Genomics 49 (1): 59–68. doi:10.1006/geno.1998.5222. PMID 9570949.
  2. 1 2 "Entrez Gene: PPP1R12B protein phosphatase 1, regulatory (inhibitor) subunit 12B".
  3. Bannert, Norbert; Vollhardt Karin; Asomuddinov Bakhtier; Haag Marion; König Herbert; Norley Stephen; Kurth Reinhard (Oct 2003). "PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits". J. Biol. Chem. (United States) 278 (43): 42190–9. doi:10.1074/jbc.M306669200. ISSN 0021-9258. PMID 12923170.

Further reading


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