PPP1R7

Protein phosphatase 1, regulatory subunit 7
Identifiers
Symbols	PPP1R7 ; SDS22
External IDs	OMIM: 602877 MGI: 1913635 HomoloGene: 2032 GeneCards: PPP1R7 Gene
Gene ontology Molecular function • protein binding • protein phosphatase type 1 regulator activity • enzyme regulator activity Cellular component • nucleus • chromosome • cytoplasm • extracellular exosome Biological process • chromosome segregation • biological_process • positive regulation of protein dephosphorylation • regulation of catalytic activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5510	66385
Ensembl	ENSG00000115685	ENSMUSG00000026275
UniProt	Q15435	Q3UM45
RefSeq (mRNA)	NM_001282409	NM_023200
RefSeq (protein)	NP_001269338	NP_075689
Location (UCSC)	Chr 2: 241.15 – 241.18 Mb	Chr 1: 93.34 – 93.37 Mb
PubMed search

Protein phosphatase 1 regulatory subunit 7 is an enzyme that in humans is encoded by the PPP1R7 gene.^[1][2][3][4]

References

1. Renouf S, Beullens M, Wera S, Van Eynde A, Sikela J, Stalmans W, Bollen M (Jan 1996). "Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1". FEBS Lett 375 (1–2): 75–8. doi:10.1016/0014-5793(95)01180-M. PMID 7498485.
2. Berry R, Stevens TJ, Walter NA, Wilcox AS, Rubano T, Hopkins JA, Weber J, Goold R, Soares MB, Sikela JM (Oct 1995). "Gene-based sequence-tagged-sites (STSs) as the basis for a human gene map". Nat Genet 10 (4): 415–23. doi:10.1038/ng0895-415. PMID 7670491.
3. Ceulemans H, Van Eynde A, Perez-Callejon E, Beullens M, Stalmans W, Bollen M (Jun 1999). "Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1". Eur J Biochem 262 (1): 36–42. doi:10.1046/j.1432-1327.1999.00344.x. PMID 10231361.
4. "Entrez Gene: PPP1R7 protein phosphatase 1, regulatory (inhibitor) subunit 7".

Further reading

• Lesage B, Beullens M, Pedelini L, et al. (2007). "A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3". Biochemistry 46 (31): 8909–19. doi:10.1021/bi7003119. PMID 17630778.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ceulemans H, Vulsteke V, De Maeyer M, et al. (2003). "Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1". J. Biol. Chem. 277 (49): 47331–7. doi:10.1074/jbc.M206838200. PMID 12226088.