PPP2R2C
| Protein phosphatase 2, regulatory subunit B, gamma | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | PPP2R2C ; B55-GAMMA; IMYPNO; IMYPNO1; PR52; PR55G | ||||||||||||
| External IDs | OMIM: 605997 MGI: 2442660 HomoloGene: 36386 ChEMBL: 2507 GeneCards: PPP2R2C Gene | ||||||||||||
| EC number | 3.1.3.16 | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5522 | 269643 | |||||||||||
| Ensembl | ENSG00000074211 | ENSMUSG00000029120 | |||||||||||
| UniProt | Q9Y2T4 | Q8BG02 | |||||||||||
| RefSeq (mRNA) | NM_001206994 | NM_172994 | |||||||||||
| RefSeq (protein) | NP_001193923 | NP_766582 | |||||||||||
| Location (UCSC) |
Chr 4: 6.32 – 6.56 Mb |
Chr 5: 36.87 – 36.96 Mb | |||||||||||
| PubMed search | |||||||||||||
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.[1][2][3]
Function
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]
References
- ↑ Torres R, Ide SE, Dehejia A, Baras A, Polymeropoulos MH (Oct 1999). "Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit". DNA Research 6 (5): 323–7. doi:10.1093/dnares/6.5.323. PMID 10574460.
- ↑ Hu P, Yu L, Zhang M, Zheng L, Zhao Y, Fu Q, Zhao S (Jul 2000). "Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16". Genomics 67 (1): 83–6. doi:10.1006/geno.2000.6219. PMID 10945473.
- 1 2 "Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform".
Further reading
- Zolnierowicz S (Oct 2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochemical Pharmacology 60 (8): 1225–35. doi:10.1016/S0006-2952(00)00424-X. PMID 11007961.
- Andersen JL, Planelles V (Jan 2005). "The role of Vpr in HIV-1 pathogenesis". Current HIV Research 3 (1): 43–51. doi:10.2174/1570162052772988. PMID 15638722.
- Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
- Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
- Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research 121 (4): 270–86. PMID 15817944.
- Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters 401 (2-3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886.
- Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
- Strack S, Zaucha JA, Ebner FF, Colbran RJ, Wadzinski BE (Mar 1998). "Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits". The Journal of Comparative Neurology 392 (4): 515–27. doi:10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3. PMID 9514514.
- "Toward a complete human genome sequence". Genome Research 8 (11): 1097–108. Nov 1998. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
- Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER (Jul 2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Research 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
- Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (Oct 2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". The Journal of Biological Chemistry 278 (42): 40829–36. doi:10.1074/jbc.M308678200. PMID 12912990.
- Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, Hahn WC (Feb 2004). "Identification of specific PP2A complexes involved in human cell transformation". Cancer Cell 5 (2): 127–36. doi:10.1016/S1535-6108(04)00026-1. PMID 14998489.
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