PPP2R5C

Protein phosphatase 2, regulatory subunit B', gamma

PDB rendering based on 2iae.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PPP2R5C ; B56G; PR61G
External IDs OMIM: 601645 MGI: 1349475 HomoloGene: 135298 GeneCards: PPP2R5C Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5527 26931
Ensembl ENSG00000078304 ENSMUSG00000017843
UniProt Q13362 Q60996
RefSeq (mRNA) NM_001161725 NM_001037934.1
RefSeq (protein) NP_001155197 NP_001074926.1
Location (UCSC) Chr 14:
101.76 – 101.93 Mb		 Chr 12:
111.69 – 111.82 Mb
PubMed search

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the PPP2R5C gene.[1][2]

Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]

Interactions

PPP2R5C has been shown to interact with PPP2R1B[3] and PPP2CA.[3][4][5]

References

  1. ↑ McCright B, Virshup DM (Nov 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". The Journal of Biological Chemistry 270 (44): 26123–8. doi:10.1074/jbc.270.44.26123. PMID 7592815.
  2. 1 2 "Entrez Gene: PPP2R5C protein phosphatase 2, regulatory subunit B', gamma isoform".
  3. 1 2 McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.
  4. ↑ Ito A, Kataoka TR, Watanabe M, Nishiyama K, Mazaki Y, Sabe H, Kitamura Y, Nojima H (Feb 2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". The EMBO Journal 19 (4): 562–71. doi:10.1093/emboj/19.4.562. PMC 305594. PMID 10675325.
  5. ↑ Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Further reading

  • Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353. 
  • Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175. 
  • Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research 121 (4): 270–86. PMID 15817944. 
  • Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Research 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026. 
  • Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044. 
  • Akiyama N, Shima H, Hatano Y, Osawa Y, Sugimura T, Nagao M (Jun 1995). "cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase". European Journal of Biochemistry / FEBS 230 (2): 766–72. doi:10.1111/j.1432-1033.1995.tb20619.x. PMID 7607250. 
  • Tehrani MA, Mumby MC, Kamibayashi C (Mar 1996). "Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle". The Journal of Biological Chemistry 271 (9): 5164–70. doi:10.1074/jbc.271.9.5164. PMID 8617797. 
  • Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA (Jul 1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits". The Biochemical Journal. 317 ( Pt 1) (Pt 1): 187–94. PMC 1217462. PMID 8694763. 
  • McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017. 
  • McCright B, Brothman AR, Virshup DM (Aug 1996). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics 36 (1): 168–70. doi:10.1006/geno.1996.0438. PMID 8812429. 
  • Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters 401 (2-3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886. 
  • Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615. 
  • Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. Journal International Du Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. 
  • Ito A, Kataoka TR, Watanabe M, Nishiyama K, Mazaki Y, Sabe H, Kitamura Y, Nojima H (Feb 2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". The EMBO Journal 19 (4): 562–71. doi:10.1093/emboj/19.4.562. PMC 305594. PMID 10675325. 
  • Ikeda S, Kishida M, Matsuura Y, Usui H, Kikuchi A (Jan 2000). "GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin". Oncogene 19 (4): 537–45. doi:10.1038/sj.onc.1203359. PMID 10698523. 
  • Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413. 
  • Muneer S, Ramalingam V, Wyatt R, Schultz RA, Minna JD, Kamibayashi C (Mar 2002). "Genomic organization and mapping of the gene encoding the PP2A B56gamma regulatory subunit". Genomics 79 (3): 344–8. doi:10.1006/geno.2002.6721. PMID 11863364. 
  • Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT (Jun 2002). "Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits". The Journal of Biological Chemistry 277 (23): 20750–5. doi:10.1074/jbc.M202992200. PMID 11929880. 
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