PPP2R5E

Protein phosphatase 2, regulatory subunit B', epsilon isoform
Identifiers
Symbol	PPP2R5E
External IDs	OMIM: 601647 MGI: 1349473 HomoloGene: 55962 GeneCards: PPP2R5E Gene
Gene ontology Molecular function • protein binding • protein phosphatase type 2A regulator activity Cellular component • protein phosphatase type 2A complex • cytoplasm Biological process • signal transduction • regulation of protein phosphatase type 2A activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5529	26932
Ensembl	ENSG00000154001	ENSMUSG00000021051
UniProt	Q16537	Q61151
RefSeq (mRNA)	NM_001282179	NM_012024
RefSeq (protein)	NP_001269108	NP_036154
Location (UCSC)	Chr 14: 63.37 – 63.54 Mb	Chr 12: 75.45 – 75.6 Mb
PubMed search

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the PPP2R5E gene.^[1][2]

Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily.^[2]

Interactions

PPP2R5E has been shown to interact with PPP2R1B^[3] and PPP2CA.^[3][4]

References

1. McCright B, Virshup DM (Nov 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". The Journal of Biological Chemistry 270 (44): 26123–8. doi:10.1074/jbc.270.44.26123. PMID 7592815.
2. "Entrez Gene: PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform".
3. McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.
4. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Further reading

• Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
• Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
• Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research 121 (4): 270–86. PMID 15817944.
• Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA (Jul 1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits". The Biochemical Journal. 317 ( Pt 1) (Pt 1): 187–94. PMC 1217462. PMID 8694763.
• McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.
• McCright B, Brothman AR, Virshup DM (Aug 1996). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics 36 (1): 168–70. doi:10.1006/geno.1996.0438. PMID 8812429.
• Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters 401 (2-3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886.
• Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
• Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
• Hrimech M, Yao XJ, Branton PE, Cohen EA (Jul 2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". The EMBO Journal 21 (14): 3918. doi:10.1093/emboj/cdf420. PMC 126131. PMID 12110603.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Dozier C, Bonyadi M, Baricault L, Tonasso L, Darbon JM (Sep 2004). "Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit". Biology of the Cell / Under the Auspices of the European Cell Biology Organization 96 (7): 509–17. doi:10.1016/j.biolcel.2004.04.010. PMID 15380617.
• Ammosova T, Washington K, Debebe Z, Brady J, Nekhai S (2006). "Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription". Retrovirology 2: 47. doi:10.1186/1742-4690-2-47. PMC 1187922. PMID 16048649.