PRIMA1

Proline rich membrane anchor 1
Identifiers
Symbols PRIMA1 ; PRIMA
External IDs OMIM: 613851 MGI: 1926097 HomoloGene: 15783 GeneCards: PRIMA1 Gene
Orthologs
Species Human Mouse
Entrez 145270 170952
Ensembl ENSG00000175785 ENSMUSG00000041669
UniProt Q86XR5 Q810F0
RefSeq (mRNA) NM_178004 NM_133364
RefSeq (protein) NP_821092 NP_579942
Location (UCSC) Chr 14:
93.72 – 93.79 Mb
Chr 12:
103.2 – 103.24 Mb
PubMed search

Proline-rich membrane anchor 1, also known as PRiMA, is a protein that in humans is encoded by the PRIMA1 gene.[1][2]

Function

PRiMA functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes.[1] This is accomplished by the proline rich anchor domain (PRAD) of PRIMA1 which anchors the tetramer of AChE into the plasma membrane of neural cells and myocytes.[3] The PRAD interacts with the C-terminal T-peptide of AChE.[4]

PRiMA plays a role in targeting AChE to the cell surface and, in neuroblastoma cells, PRiMA the limiting factor of such targeting.[2] In both mice and humans, PRiMA exists as two alternative splice variants that differ in their cytoplasmic regions.

Clinical significance

The severity of neurogenerative diseases, such as Alzheimer’s, can be related to the degradation of AChE.[5]

References

  1. 1 2 "Entrez Gene: proline rich membrane anchor 1".
  2. 1 2 Perrier AL, Massoulié J, Krejci E (Jan 2002). "PRiMA: the membrane anchor of acetylcholinesterase in the brain". Neuron 33 (2): 275–85. doi:10.1016/S0896-6273(01)00584-0. PMID 11804574.
  3. Xie HQ, Siow NL, Peng HB, Massoulié J, Tsim KW (Dec 2005). "Regulation of PRiMA: membrane anchor of acetylcholinesterase (AChE) in neuron and muscle". Chemico-Biological Interactions. 157-158: 432. doi:10.1016/j.cbi.2005.10.093. PMID 16429581.
  4. Perrier NA, Khérif S, Perrier AL, Dumas S, Mallet J, Massoulié J (Oct 2003). "Expression of PRiMA in the mouse brain: membrane anchoring and accumulation of 'tailed' acetylcholinesterase". The European Journal of Neuroscience 18 (7): 1837–47. doi:10.1046/j.1460-9568.2003.02914.x. PMID 14622217.
  5. Atack JR, Perry EK, Bonham JR, Perry RH, Tomlinson BE, Blessed G, Fairbairn A (Sep 1983). "Molecular forms of acetylcholinesterase in senile dementia of Alzheimer type: selective loss of the intermediate (10S) form". Neuroscience Letters 40 (2): 199–204. doi:10.1016/0304-3940(83)90302-6. PMID 6633975.

Further reading


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