PRINS (gene)

Psoriasis associated non-protein coding RNA induced by stress
Identifiers
Symbols	PRINS ; NCRNA00074
External IDs	GeneCards: PRINS Gene
Gene ontology
Orthologs
Species	Human	Mouse
Entrez	100169750	n/a
Ensembl	ENSG00000238115	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	Chr 10: 24.54 – 24.54 Mb	n/a
PubMed search		n/a

PRINS (psoriasis associated RNA induced by stress) is a long non-coding RNA. Its expression is induced by stress, and it may have a protective role in cells exposed to stress. It is over-expressed in the skin of patients with psoriasis.^[1] It regulates G1P3, a gene encoding a protein with anti-apoptotic effects in keratinocytes. Overexpression of PRINS may contribute to psoriasis via the down-regulation of G1P3.^[2]

See also

• Long noncoding RNA

References

1. Sonkoly E, Bata-Csorgo Z, Pivarcsi A, et al. (June 2005). "Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS". J. Biol. Chem. 280 (25): 24159–67. doi:10.1074/jbc.M501704200. PMID 15855153.
2. Szegedi K, Sonkoly E, Nagy N, et al. (March 2010). "The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS". Exp. Dermatol. 19 (3): 269–78. doi:10.1111/j.1600-0625.2010.01066.x. PMID 20377629.

Further reading

• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.