PRKAR1B

Protein kinase, cAMP-dependent, regulatory, type I, beta
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4DIN​, 4F9K​
Identifiers
Symbols	PRKAR1B ; PRKAR1
External IDs	OMIM: 176911 MGI: 97759 HomoloGene: 37665 ChEMBL: 2320 GeneCards: PRKAR1B Gene
EC number	2.7.11.1
Gene ontology Molecular function • cAMP-dependent protein kinase inhibitor activity • cAMP-dependent protein kinase regulator activity • cAMP binding • protein kinase A catalytic subunit binding Cellular component • cytosol • plasma membrane • cAMP-dependent protein kinase complex • ciliary base Biological process • renal water homeostasis • energy reserve metabolic process • protein phosphorylation • water transport • signal transduction • epidermal growth factor receptor signaling pathway • activation of phospholipase C activity • blood coagulation • learning or memory • fibroblast growth factor receptor signaling pathway • activation of protein kinase A activity • small molecule metabolic process • innate immune response • neurotrophin TRK receptor signaling pathway • regulation of insulin secretion • transmembrane transport • cellular response to glucagon stimulus • negative regulation of cAMP-dependent protein kinase activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5575	19085
Ensembl	ENSG00000188191	ENSMUSG00000025855
UniProt	P31321	P12849
RefSeq (mRNA)	NM_001164758	NM_001253890
RefSeq (protein)	NP_001158230	NP_001240819
Location (UCSC)	Chr 7: 0.55 – 0.73 Mb	Chr 5: 139.02 – 139.15 Mb
PubMed search

cAMP-dependent protein kinase type I-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR1B gene.^[1][2][3]

Clinical significance

Mutations in PRKAR1B cause neurodegenerative disorder .^[4]

Interactions

PRKAR1B has been shown to interact with AKAP1^[5] and PRKAR1A.^[5][6]

References

1. Solberg R, Sistonen P, Träskelin AL, Bérubé D, Simard J, Krajci P, Jahnsen T, de la Chapelle A (Dec 1992). "Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7". Genomics 14 (1): 63–9. doi:10.1016/S0888-7543(05)80284-8. PMID 1358799.
2. Scambler P, Oyen O, Wainwright B, Farrall M, Law HY, Estivill X, Sandberg M, Williamson R, Jahnsen T (Dec 1987). "Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis". Am J Hum Genet 41 (5): 925–32. PMC 1684338. PMID 3479018.
3. "Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta".
4. Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Bakker EB, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J (2014). "PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology". Brain 137 (Pt 5): 1361–73. doi:10.1093/brain/awu067. PMID 24722252.
5. Carlson CR, Ruppelt A, Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
6. Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (Oct 1993). "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. PMID 8407966.

Further reading

• Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current drug targets 7 (12): 1595–606. doi:10.2174/138945006779025338. PMID 17168834.
• Solberg R, Taskén K, Keiserud A, Jahnsen T (1991). "Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases". Biochem. Biophys. Res. Commun. 176 (1): 166–72. doi:10.1016/0006-291X(91)90904-L. PMID 1708242.
• Hofmann B, Nishanian P, Baldwin RL, Insixiengmay P, Nel A, Fahey JL (1991). "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". J. Immunol. 145 (11): 3699–705. PMID 1978848.
• Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahey JL (1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6676–80. doi:10.1073/pnas.90.14.6676. PMC 46995. PMID 7688126.
• Solberg R, Taskén K, Wen W, Coghlan VM, Meinkoth JL, Scott JD, Jahnsen T, Taylor SS (1994). "Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells". Exp. Cell Res. 214 (2): 595–605. doi:10.1006/excr.1994.1297. PMID 7925653.
• Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS 8 (7): 1016–7. doi:10.1097/00002030-199407000-00025. PMID 7946090.
• Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (1993). "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. PMID 8407966.
• Swingler S, Gallay P, Camaur D, Song J, Abo A, Trono D (1997). "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix". J. Virol. 71 (6): 4372–7. PMC 191654. PMID 9151826.
• Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
• Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F (1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways". AIDS Res. Hum. Retroviruses 14 (10): 825–33. doi:10.1089/aid.1998.14.825. PMID 9671211.
• Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685.
• Laxminarayana D, Khan IU, Mishra N, Olorenshaw I, Taskén K, Kammer GM (1999). "Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes". J. Immunol. 162 (9): 5639–48. PMID 10228048.
• Adachi M, Lewis EJ (2002). "The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status". J. Biol. Chem. 277 (25): 22915–24. doi:10.1074/jbc.M201695200. PMID 11943777.
• Oliver CJ, Terry-Lorenzo RT, Elliott E, Bloomer WA, Li S, Brautigan DL, Colbran RJ, Shenolikar S (2002). "Targeting Protein Phosphatase 1 (PP1) to the Actin Cytoskeleton: the Neurabin I/PP1 Complex Regulates Cell Morphology". Mol. Cell. Biol. 22 (13): 4690–701. doi:10.1128/MCB.22.13.4690-4701.2002. PMC 133892. PMID 12052877.
• Nguyen DT, Rovira II, Finkel T (2002). "Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A". FEBS Lett. 521 (1–3): 170–4. doi:10.1016/S0014-5793(02)02868-5. PMID 12067711.
• Mucignat-Caretta C, Caretta A (2003). "Localization of Triton-insoluble cAMP-dependent kinase type RIbeta in rat and mouse brain". J. Neurocytol. 30 (11): 885–94. doi:10.1023/A:1020613132648. PMID 12373096.
• Carlson CR, Ruppelt A, Taskén K (2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.