PRSS22

Protease, serine, 22
Identifiers
Symbols	PRSS22 ; BSSP-4; SP001LA; hBSSP-4
External IDs	OMIM: 609343 MGI: 1918085 HomoloGene: 23344 GeneCards: PRSS22 Gene
Gene ontology Molecular function • serine-type endopeptidase activity Cellular component • extracellular region Biological process • proteolysis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64063	70835
Ensembl	ENSG00000005001	ENSMUSG00000045027
UniProt	Q9GZN4	Q9ER10
RefSeq (mRNA)	NM_022119	NM_133731
RefSeq (protein)	NP_071402	NP_598492
Location (UCSC)	Chr 16: 2.85 – 2.86 Mb	Chr 17: 23.99 – 24 Mb
PubMed search

Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon, is an enzyme that in humans is encoded by the PRSS22 gene.^[1][2][3]

This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16.^[1]

See also

• tryptase

References

1. "Entrez Gene: protease".
2. Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL (December 2001). "Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells". J. Biol. Chem. 276 (52): 49169–82. doi:10.1074/jbc.M108677200. PMID 11602603.
3. Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL (May 2005). "Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22". Blood 105 (10): 3893–901. doi:10.1182/blood-2003-10-3501. PMC 1895090. PMID 15701722.

Further reading

• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Martin J, Han C, Gordon LA, et al. (2004). "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.
• Mitsui S, Okui A, Kominami K, et al. (2005). "A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells.". FEBS J. 272 (19): 4911–23. doi:10.1111/j.1742-4658.2005.04901.x. PMID 16176265.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.