PTBP2

Polypyrimidine tract binding protein 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2CQ1​
Identifiers
Symbols	PTBP2 ; PTB; PTBLP; brPTB; nPTB; nPTB5; nPTB6; nPTB7; nPTB8
External IDs	OMIM: 608449 MGI: 1860489 HomoloGene: 23162 GeneCards: PTBP2 Gene
Gene ontology Molecular function • nucleotide binding • mRNA binding Cellular component • spliceosomal complex Biological process • mRNA splice site selection • negative regulation of RNA splicing Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	58155	56195
Ensembl	ENSG00000117569	ENSMUSG00000028134
UniProt	Q9UKA9	Q91Z31
RefSeq (mRNA)	NM_021190	NM_019550
RefSeq (protein)	NP_067013	NP_062423
Location (UCSC)	Chr 1: 97.19 – 97.28 Mb	Chr 3: 119.72 – 119.78 Mb
PubMed search

Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene.^[1][2]

Function

The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract-binding protein PTBP1 but it is expressed primarily in the brain.^[2]

References

1. Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL (October 2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
2. "Entrez Gene: PTBP2 polypyrimidine tract binding protein 2".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.