PVT1

Pvt1 oncogene (non-protein coding)
Identifiers
Symbols	PVT1 ; LINC00079; NCRNA00079; onco-lncRNA-100
External IDs	OMIM: 165140 HomoloGene: 90803 GeneCards: PVT1 Gene
Gene ontology
Orthologs
Species	Human	Mouse
Entrez	5820	n/a
Ensembl	ENSG00000249859	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	Chr 8: 127.79 – 128.1 Mb	n/a
PubMed search		n/a

Pvt1 oncogene (non-protein coding), also known as PVT1, is a long non-coding RNA gene.^[1] In mice, this gene was identified as a breakpoint site in chromosome 6;15 translocations. These translocations are associated with murine plasmacytomas.^[2] The equivalent translocation in humans is t(2;8), which is associated with a rare variant of Burkitt's lymphoma.^[3] In rats, this breakpoint was shown to be a common site of proviral integration in retrovirally induced T lymphomas.^[4] Transcription of PVT1 is regulated by Myc.^[5]

References

1. "Entrez Gene: PVT1 Pvt1 oncogene homolog, MYC activator (mouse)".
2. Cory S, Graham M, Webb E, Corcoran L, Adams JM (1985). "Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene.". EMBO J 4 (3): 675–81. PMC 554241. PMID 3924592.
3. Graham M, Adams JM (1986). "Chromosome 8 breakpoint far 3' of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus.". EMBO J 5 (11): 2845–51. PMC 1167233. PMID 3024964.
4. Villeneuve L, Rassart E, Jolicoeur P, Graham M, Adams JM (1986). "Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas.". Mol Cell Biol 6 (5): 1834–7. PMC 367714. PMID 3785181.
5. Carramusa L, Contino F, Ferro A, Minafra L, Perconti G, Giallongo A, et al. (2007). "The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells.". J Cell Physiol 213 (2): 511–8. doi:10.1002/jcp.21133. PMID 17503467.

Further reading

• Guan Y, Kuo WL, Stilwell JL, et al. (2007). "Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.". Clin. Cancer Res. 13 (19): 5745–55. doi:10.1158/1078-0432.CCR-06-2882. PMID 17908964.
• Millis MP, Bowen D, Kingsley C, et al. (2007). "Variants in the plasmacytoma variant translocation gene (PVT1) are associated with end-stage renal disease attributed to type 1 diabetes.". Diabetes 56 (12): 3027–32. doi:10.2337/db07-0675. PMID 17881614.
• Carramusa L, Contino F, Ferro A, et al. (2008). "The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells.". J. Cell. Physiol. 213 (2): 511–8. doi:10.1002/jcp.21133. PMID 17503467.
• Hanson RL, Craig DW, Millis MP, et al. (2007). "Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study.". Diabetes 56 (4): 975–83. doi:10.2337/db06-1072. PMID 17395743.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Graham M, Adams JM (1987). "Chromosome 8 breakpoint far 3' of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus.". EMBO J. 5 (11): 2845–51. PMC 1167233. PMID 3024964.
• Shtivelman E, Bishop JM (1989). "The PVT gene frequently amplifies with MYC in tumor cells.". Mol. Cell. Biol. 9 (3): 1148–54. PMC 362705. PMID 2725491.
• Shtivelman E, Henglein B, Groitl P, et al. (1989). "Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma.". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3257–60. doi:10.1073/pnas.86.9.3257. PMC 287109. PMID 2470097.
• Shtivelman E, Bishop JM (1990). "Effects of translocations on transcription from PVT.". Mol. Cell. Biol. 10 (4): 1835–9. PMC 362296. PMID 2181290.