Penicillopepsin

Penicillopepsin
Identifiers
EC number 3.4.23.20
CAS number 2620465
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Penicillopepsin (EC 3.4.23.20, peptidase A, Penicillium janthinellum aspartic proteinase, acid protease A, Penicillium citrinum acid proteinase, Penicillium cyclopium acid proteinase, Penicillium expansum acid proteinase, Penicillium janthinellum acid proteinase, Penicillium expansum aspartic proteinase, Penicillium aspartic proteinase, Penicillium caseicolum aspartic proteinase, Penicillium roqueforti acid proteinase, Penicillium duponti aspartic proteinase, Penicillium citrinum aspartic proteinase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen

This enzyme is present in fungus Penicillium janthinellum.

References

  1. ↑ Mains, G., Takahashi, M., Sodek, J. and Hofmann, T. (1971). "The specificity of penicillopepsin". Can. J. Biochem. 49: 1134–1149. doi:10.1139/o71-164. PMID 4946839.
  2. ↑ Zevaco, C., Hermier, J. and Gripon, J.-C. (1973). "Le système protéolytique de Penicillium roqueforti. II - Purification et propriétés de la protéase acide". Biochimie 55: 1353–1360. doi:10.1016/s0300-9084(74)80543-2. PMID 4790849.
  3. ↑ Emi, S., Myers, D.V. and Iacobucci, G.A. (1976). "Purification and properties of the thermostable acid protease of Penicillium duponti". Biochemistry 15: 842–848. doi:10.1021/bi00649a018. PMID 2287.
  4. ↑ Hofmann, T. (1976). "Penicillopepsin". Methods Enzymol. 45: 434–450. doi:10.1016/s0076-6879(76)45038-3. PMID 1012008.
  5. ↑ Hsu, I.-N., Delbaere, L.T.J., James, M.N.G. and Hofmann, T. (1977). "Penicillopepsin from Penicillium janthinellum crystal structure at 2.8 Å and sequence homology with porcine pepsin". Nature 266: 140–144. doi:10.1038/266140a0. PMID 323722.

External links

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