Pentavalent antimonial

Pentavalent antimonials (also abbreviated pentavalent Sb or SbV) are a group of compounds used for the treatment of leishmaniasis. They are also called pentavalent antimony compounds.

Types

The first pentavalent antimonial used was urea stibamine: first introduced in the 1930s, it fell out of favour in the 1950s due to higher toxicity compared to sodium stibogluconate.

The compounds currently available for clinical use are:

The pentavalent antimonials can only be given by injection: there are no oral preparations available.

Alternatives

In many countries, widespread resistance to antimony has meant that amphotericin or miltefosine are now used in preference.[2]

Side effects

Cardiotoxicity, reversible renal failure, pancreatitis, anemia, leukopenia, rash, headache, abdominal pain, nausea, vomiting, arthralgia, myalgia, thrombocytopenia, and transaminase elevation.

References

  1. Lima EB, Porto C, Motta JCO, Sampaio RNR.Treatment of American cutaneous leishmaniasis. An Bras Dermatol. 2007;82(2):111-24.
  2. Olliaro P, Guerin P, Gerstl S, (2005). "Treatment options for visceral leishmaniasis: a systematic review of clinical studies done in India, 1980–2004". Lancet Infect Dis 5 (12): 763–774. doi:10.1016/S1473-3099(05)70296-6. PMID 16310148.


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