Phorbol 12,13-dibutyrate

Phorbol 12,13-dibutyrate

Names
Other names Phorbol dibutyrate; Phorbol 12,13-dibutanoate
Identifiers
CAS Number	37558-16-0
Abbreviations	PDBu
Jmol interactive 3D	Image
PubChem	37783
SMILES CCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)CCC)O)C
Properties
Chemical formula	C28H40O8
Molar mass	504.62 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Phorbol 12,13-dibutyrate (PDBu) is a phorbol ester which is one of the constituents of croton oil. As an activator of protein kinase C, it is a weak tumor promoter compared to 12-O-tetradecanoylphorbol-13-acetate.^[1]

PDBu is widely used as a chemical reagent because of its solubility in water and other organic solvents.

References

1. Blumberg P M; Delclos K B; Dunn J A; Jaken S; Leach K L; Yeh E (1983). "Phorbol ester receptors and the in vitro effects of tumor promoters". Annals of the New York Academy of Sciences 407: 303–315. doi:10.1111/j.1749-6632.1983.tb47836.x. PMID 6309054.