Phosphatidylinositol transfer protein, alpha

Phosphatidylinositol transfer protein, alpha
PDB rendering based on 1kcm.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1UW5​
Identifiers
Symbols	PITPNA ; HEL-S-36; PI-TPalpha; PITPN; VIB1A
External IDs	OMIM: 600174 MGI: 99887 HomoloGene: 55958 GeneCards: PITPNA Gene
Gene ontology Molecular function • lipid binding • phosphatidylcholine transporter activity • phosphatidylinositol transporter activity Cellular component • cytoplasm • myelin sheath • extracellular exosome Biological process • lipid metabolic process • axon guidance • visual perception • phospholipid transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5306	18738
Ensembl	ENSG00000174238	ENSMUSG00000017781
UniProt	Q00169	P53810
RefSeq (mRNA)	NM_006224	NM_008850
RefSeq (protein)	NP_006215	NP_032876
Location (UCSC)	Chr 17: 1.52 – 1.56 Mb	Chr 11: 75.59 – 75.63 Mb
PubMed search

Phosphatidylinositol transfer protein alpha isoform is a protein that in humans is encoded by the PITPNA gene.^[1]

Phosphatidylinositol transfer proteins are a diverse set of cytosolic phospholipid transfer proteins that are distinguished by their ability to transfer phospholipids between membranes in vitro (Wirtz, 1991).^[2]

References

1. Hay JC, Martin TF (Jan 1994). "Phosphatidylinositol transfer protein required for ATP-dependent priming of Ca(2+)-activated secretion". Nature 366 (6455): 572–5. doi:10.1038/366572a0. PMID 8255295.
2. "Entrez Gene: PITPNA phosphatidylinositol transfer protein, alpha".

Further reading

• Wirtz KW (1991). "Phospholipid transfer proteins". Annu. Rev. Biochem. 60: 73–99. doi:10.1146/annurev.bi.60.070191.000445. PMID 1883207.

External links

• UMich Orientation of Proteins in Membranes families/superfamily-147