Phosphinothricin acetyltransferase

Phosphinothricin acetyltransferase
Identifiers
EC number 2.3.1.183
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Phosphinothricin acetyltransferase (EC 2.3.1.183, PAT, PPT acetyltransferase, Pt-N-acetyltransferase, ac-Pt) is an enzyme with systematic name acetyl-CoA:phosphinothricin N-acetyltransferase.[1][2] This enzyme catalyses the following chemical reaction

acetyl-CoA + phosphinothricin \rightleftharpoons CoA + N-acetylphosphinothricin

The substrate phosphinothricin is used as a nonselective herbicide and is a potent inhibitor of EC 6.3.1.2.

References

  1. Botterman, J., Gosselé, V., Thoen, C. and Lauwereys, M. (1991). "Characterization of phosphinothricin acetyltransferase and C-terminal enzymatically active fusion proteins". Gene 102: 33–37. doi:10.1016/0378-1119(91)90534-i. PMID 1864506.
  2. Dröge-Laser, W., Siemeling, U., Pühler, A. and Broer, I. (1994). "The metabolites of the herbicide L-phosphinothricin (glufosinate) (identification, stability, and mobility in transgenic, herbicide-resistant, and untransformed plants)". Plant Physiol. 105: 159–166. doi:10.1104/pp.105.1.159. PMID 12232195.

External links

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