Phosphoramidate

A phosphoramidate is a phosphate that has an NR₂ instead of an OH group. The structure of phosphoramidic acid (phosphoramidate), (HO)₂PONH₂, is present in PubChem.^[1]
A phosphorodiamidate is a phosphate that has two of its OH groups substituted by NR₂ groups.

Examples

Two examples of natural phosphoramidates are phosphocreatine and the phosporamidate formed when histidine residues in histidine kinases are phosphorylated.^[2] An example of a phosphorodiamidate is Morpholino which is used in molecular biology.

References

↑ "phosphoramidic acid - PubChem". Pubchem.ncbi.nlm.nih.gov. 2013-09-25. Retrieved 2014-01-14.
↑ "Two-Component Signal Transduction". Annual Review of Biochemistry. 2000-07-01. Retrieved 2015-06-07.

Organophosphorus

Only P-O bonds

P(III)	Phosphite/Organophosphite

P(V)	Phosphate/Organophosphate

With P-C bonds

One P-C bonds

P(III)	Phosphonite

P(V)	Phosphonate

Two P-C bonds

P(III)	Phosphinite

P(V)	Phosphinate

Three P-C bonds

P(III)	Phosphine

P(V)	Phosphine oxide

With P-N bonds

One P-N bond

P(III)	Phosphoramidite e.g. Nucleoside phosphoramidite

P(V)	Phosphoramidate e.g. Phosphocreatine

Two P-N bond

P(III)	Phosphorodiamidite

P(V)	Phosphorodiamidate e.g. Morpholino Cyclophosphamide

Three P-N bond

P(V)	Phosphoramide e.g. Hexamethylphosphoramide Metepa

With P-C and P-N bonds

One P-C bond and one P-N bond

P(V)	Phosphonamidate

One P-C bond and two P-N bond

P(V)	Phosphonamide

Two P-C bond and one P-N bond

P(V)	Phosphinamide

With P-S bonds

One P-S bond

P(III)	Phosphorothioite

P(V)	Phosphorothioate

Two P-S bond

P(III)	Phosphorodithioite

P(V)	Phosphorodithioate

This article is issued from Wikipedia - version of the Sunday, December 06, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

Phosphoramidate

Examples

See also

References