Phosphoserine transaminase

Phosphoserine transaminase
Identifiers
EC number 2.6.1.52
CAS number 9030-90-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Phosphoserine transaminase (EC 2.6.1.52, PSAT, phosphoserine aminotransferase, 3-phosphoserine aminotransferase, hydroxypyruvic phosphate-glutamic transaminase, L-phosphoserine aminotransferase, phosphohydroxypyruvate transaminase, phosphohydroxypyruvic-glutamic transaminase, 3-O-phospho-L-serine:2-oxoglutarate aminotransferase, SerC, PdxC, 3PHP transaminase) is an enzyme with systematic name O-phospho-L-serine:2-oxoglutarate aminotransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(1) O-phospho-L-serine + 2-oxoglutarate \rightleftharpoons 3-phosphonooxypyruvate + L-glutamate
(2) 4-phosphonooxy-L-threonine + 2-oxoglutarate \rightleftharpoons (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate

This enzyme is a pyridoxal-phosphate protein.

See also

References

  1. ↑ Hirsch, H. and Greenberg, D.M. (1967). "Studies on phosphoserine aminotransferase of sheep brain". J. Biol. Chem. 242 (9): 2283–2287. PMID 6022873.
  2. ↑ Pizer, L.I. (1963). "The pathway and control of serine biosynthesis in Escherichia coli". J. Biol. Chem. 238: 3934–3944. PMID 14086727.
  3. ↑ Zhao, G. and Winkler, M.E. (1996). "A novel α-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria". J. Bacteriol. 178 (1): 232–239. PMC 177644. PMID 8550422.
  4. ↑ Drewke, C., Klein, M., Clade, D., Arenz, A., Müller, R. and Leistner, E. (1996). "4-O-phosphoryl-L-threonine, a substrate of the pdxC(serC) gene product involved in vitamin B6 biosynthesis". FEBS Lett. 390 (2): 179–182. doi:10.1016/0014-5793(96)00652-7. PMID 8706854.
  5. ↑ Zhao, G. and Winkler, M.E. (1996). "4-Phospho-hydroxy-L-threonine is an obligatory intermediate in pyridoxal 5′-phosphate coenzyme biosynthesis in Escherichia coli K-12". FEMS Microbiol. Lett. 135 (2-3): 275–280. doi:10.1111/j.1574-6968.1996.tb08001.x. PMID 8595869.

External links

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