Phosphosulfolactate synthase

phosphosulfolactate synthase
Identifiers
EC number	4.4.1.19
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a phosphosulfolactate synthase (EC 4.4.1.19) is an enzyme that catalyzes the chemical reaction

(2R)-2-O-phospho-3-sulfolactate $\rightleftharpoons$ phosphoenolpyruvate + hydrogen sulfite

Hence, this enzyme has one substrate, (2R)-2-O-phospho-3-sulfolactate, and two products, phosphoenolpyruvate and hydrogen sulfite.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is (2R)-2-O-phospho-3-sulfolactate hydrogen-sulfite-lyase (phosphoenolpyruvate-forming). Other names in common use include (2R)-phospho-3-sulfolactate synthase, and (2R)-O-phospho-3-sulfolactate sulfo-lyase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U83.

References

• Graham DE, Xu H, White RH (2002). "Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes". J. Biol. Chem. 277 (16): 13421–9. doi:10.1074/jbc.M201011200. PMID 11830598.