Piers Nash

Piers David Nash
Nash in 2014
Born	(1969-08-08) 8 August 1969 Exeter, England
Nationality	UK, Canada, US
Fields	Biochemistry, cell biology
Institutions	University of Chicago
Alma mater	University of Alberta University of Guelph Booth School of Business
Doctoral advisor	Grant McFadden
Doctoral students	Bernard Liu, Ilana Berlin, Maria Sierra, Brett Engelmann
Known for	Cellular signal transduction
Influences	Anthony Pawson

Piers David Nash (born 8 August 1969) is the director of business development and outreach University of Chicago's Center for Data Intensive Science. He is the son of academic Roger Nash.

Early life and education

Born in Exeter, England, and grew up in Sudbury, Ontario, Canada. In high school he competed in the Canada-Wide Science Fair in five successive years (1983–87), winning awards on each occasion. In 1985 he was selected to represent Canada as one of two youth delegates to the Nobel Prize lectures and ceremony in Stockholm, Sweden as part of the Stockholm International Youth Science Seminar. He received a BSc with honours in biochemistry from the University of Guelph, and the Chemical Institute of Canada prize for the top of class. He received a PhD in 1999 from the University of Alberta working in the laboratory of Dr. Grant McFadden investigating poxviral immunomodulatory proteins. His doctoral thesis focused on the enzymology and biological properties of the Myxoma virus encoded serine proteinase inhibitor (serpin), SERP-1. He completed postdoctoral research with Anthony Pawson at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and the University of Toronto from June 1999 to December 2003.

Career

He was a professor in the Ben May Department for Cancer Research and a Scientist of the Comprehensive Cancer Center at the University of Chicago from 2004–2012 and a fellow of the Institute for Genomics and Systems Biology^[1] from 2006–2012. As a scientist he investigates protein–protein interactions involved in signal transduction, and the molecular mechanisms by which cells respond to external cues. His work at the University of Chicago focused on understanding the SH2 domain at a systems level and investigating the role of ubiquitination in controlling endocytosis and modulating signal transduction. Earlier work focused on the emergent properties of complex systems such as ultrasensitivity (all-or-none switches) at critical junctures in the cell cycle. In 2014, Nash received an MBA with a concentration in finance awarded with high honors from the University of Chicago Booth School of Business.

ResearchGate reports 54 peer-reviewed published works in a wide range of fields, including signal transduction, cell biology, molecular evolution, cell cycle, cognition and memory, meteorology, and pedagogy.^[2] Scopus notes an h-index of 26 and 3530 citations^[3] on 44 publications tracked in that database since 1996.

Publications

Research Papers

Nash, P. (1984). "Differential Effects of Wind Speed on Low Temperature Evaporation". Chinook 6: 92–3.
Nash, C. H.; Nash, P. (1986). "Correlates of Colour Memory: A Neglected Field of Research". Future Health 8: 15–6.
Nash, Piers D.; Davison, Laura (Winter 1989). "What Gifted Secondary School Students Tell about Their School Programs". Canadian Journal of Education 14 (1): 109–18. doi:10.2307/1495206. JSTOR 1495206.
Maksymowych, WP; Nation, N; Nash, P; Macen, J; Lucas, A; McFadden, G; Russell, AS (1996). "Amelioration of antigen induced arthritis in rabbits treated with a secreted viral serine proteinase inhibitor". The Journal of rheumatology 23 (5): 878–82. PMID 8724302.
Lucas, A.; Liu, L.-y.; Macen, J.; Nash, P.; Dai, E.; Stewart, M.; Graham, K.; Etches, W.; et al. (1996). "Virus-Encoded Serine Proteinase Inhibitor SERP-1 Inhibits Atherosclerotic Plaque Development After Balloon Angioplasty". Circulation 94 (11): 2890–900. doi:10.1161/01.CIR.94.11.2890. PMID 8941118.
Nash, P.; Whitty, A; Handwerker, J; Macen, J; McFadden, G (1998). "Inhibitory Specificity of the Anti-inflammatory Myxoma Virus Serpin, SERP-1". Journal of Biological Chemistry 273 (33): 20982–91. doi:10.1074/jbc.273.33.20982. PMID 9694848.
Christov, Alexander; Dai, Erbin; Liu, Liying; Miller, Leslie W.; Nash, Piers; Lalani, Alshad; McFadden, Grant; Nation, Patric N.; et al. (1999). "Detection of transplant vasculopathy in a rat aortic allograft model by fluorescence spectroscopic optical analysis". Lasers in Surgery and Medicine 24 (5): 346–59. doi:10.1002/(SICI)1096-9101(1999)24:5<346::AID-LSM5>3.0.CO;2-K. PMID 10406475.
Miller, L. W.; Dai, E.; Nash, P.; Liu, L.; Icton, C.; Klironomos, D.; Fan, L.; Nation, P. N.; et al. (2000). "Inhibition of Transplant Vasculopathy in a Rat Aortic Allograft Model After Infusion of Anti-Inflammatory Viral Serpin". Circulation 101 (13): 1598–605. doi:10.1161/01.CIR.101.13.1598. PMID 10747355.
Lucas, A; Dai, E; Liu, L; Guan, H; Nash, P; McFadden, G; Miller, L (2000). "Transplant vasculopathy: Viral anti-inflammatory serpin regulation of atherogenesis". The Journal of Heart and Lung Transplantation 19 (11): 1029–38. doi:10.1016/S1053-2498(00)00190-X. PMID 11077219.
Nash, P; Barry, M; Seet, BT; Veugelers, K; Hota, S; Heger, J; Hodgkinson, C; Graham, K; et al. (2000). "Post-translational modification of the myxoma-virus anti-inflammatory serpin SERP-1 by a virally encoded sialyltransferase". The Biochemical Journal 347 (Pt 2): 375–82. doi:10.1042/0264-6021:3470375. PMC 1220969. PMID 10749666.
Christov, Alexander; Dai, Erbin; Drangova, Maria; Liu, Liying; Abela, George S.; Nash, Piers; McFadden, Grant; Lucas, Alexandra (2007). "Optical Detection of Triggered Atherosclerotic Plaque Disruption by Fluorescence Emission Analysis". Photochemistry and Photobiology 72 (2): 242–52. doi:10.1562/0031-8655(2000)0720242ODOTAP2.0.CO2. PMID 10946579.
Nash, Piers; McFadden, Grant; Whitty, Adrian (2000). "Application of linear free energy relationships to the serpin–proteinase inhibition mechanism". FEBS Letters 475 (1): 1–6. doi:10.1016/S0014-5793(00)01620-3. PMID 10854846.
Nash, Piers; Tang, Xiaojing; Orlicky, Stephen; Chen, Qinghua; Gertler, Frank B.; Mendenhall, Michael D.; Sicheri, Frank; Pawson, Tony; Tyers, Mike (2001). "Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication". Nature 414 (6863): 514–21. Bibcode:2001Natur.414..514N. doi:10.1038/35107009. PMID 11734846.

This article was the focus of the following reviews and comments:

Ferrell, James E. (2001). "Cell cycleSix steps to destruction". Nature 414 (6863): 498–9. Bibcode:2001Natur.414..498F. doi:10.1038/35107180. PMID 11734834.

Deshaies, Raymond J.; Ferrell Jr., James E. (2001). "Multisite Phosphorylation and the Countdown to S Phase". Cell 107 (7): 819–22. doi:10.1016/S0092-8674(01)00620-1. PMID 11779457.

Harper, J.Wade (2002). "A phosphorylation-driven ubiquitination switch for cell-cycle control". Trends in Cell Biology 12 (3): 104–7. doi:10.1016/S0962-8924(01)02238-3. PMID 11859016.

Tromans, Amanda (2001). "Switching on S phase". Nature Reviews Molecular Cell Biology 2 (12): 873. doi:10.1038/35103051. PMID 11733763.

Adler, E. M.; Gough, N. R.; Ray, L. B. (2005). "2004: Signaling Breakthroughs of the Year". Science Signaling 2005 (265): eg1. doi:10.1126/stke.2652005eg1.

Berry, Donna M.; Nash, Piers; Liu, Stanley K.-W.; Pawson, Tony; McGlade, C.Jane (2002). "A High-Affinity Arg-X-X-Lys SH3 Binding Motif Confers Specificity for the Interaction between Gads and SLP-76 in T Cell Signaling". Current Biology 12 (15): 1336–41. doi:10.1016/S0960-9822(02)01038-2. PMID 12176364.
Tong, J.; Elowe, S; Nash, P; Pawson, T (2002). "Manipulation of EphB2 Regulatory Motifs and SH2 Binding Sites Switches MAPK Signaling and Biological Activity". Journal of Biological Chemistry 278 (8): 6111–9. doi:10.1074/jbc.M208972200. PMID 12486127.
Bladt, F.; Aippersbach, E.; Gelkop, S.; Strasser, G. A.; Nash, P.; Tafuri, A.; Gertler, F. B.; Pawson, T. (2003). "The Murine Nck SH2/SH3 Adaptors Are Important for the Development of Mesoderm-Derived Embryonic Structures and for Regulating the Cellular Actin Network". Molecular and Cellular Biology 23 (13): 4586–97. doi:10.1128/MCB.23.13.4586-4597.2003. PMC 164855. PMID 12808099.
Liu, Qin; Berry, Donna; Nash, Piers; Pawson, Tony; McGlade, C.Jane; Li, Shawn Shun-Cheng (2003). "Structural Basis for Specific Binding of the Gads SH3 Domain to an RxxK Motif-Containing SLP-76 Peptide". Molecular Cell 11 (2): 471–81. doi:10.1016/S1097-2765(03)00046-7. PMID 12620234.
Leong, H.; Sloan, JR; Nash, PD; Greene, GL (2005). "Recruitment of Histone Deacetylase 4 to the N-Terminal Region of Estrogen Receptor". Molecular Endocrinology 19 (12): 2930–42. doi:10.1210/me.2005-0178. PMID 16051668.
Dai, E.; Viswanathan, K; Sun, YM; Li, X; Liu, LY; Togonu-Bickersteth, B; Richardson, J; MacAulay, C; et al. (2006). "Identification of Myxomaviral Serpin Reactive Site Loop Sequences That Regulate Innate Immune Responses". Journal of Biological Chemistry 281 (12): 8041–50. doi:10.1074/jbc.M509454200. PMID 16407226.
Liu, Bernard A.; Jablonowski, Karl; Raina, Monica; Arcé, Michael; Pawson, Tony; Nash, Piers D. (2006). "The Human and Mouse Complement of SH2 Domain Proteins—Establishing the Boundaries of Phosphotyrosine Signaling". Molecular Cell 22 (6): 851–68. doi:10.1016/j.molcel.2006.06.001. PMID 16793553.
Zhang, M; Veselits, M; O'Neill, S; Hou, P; Reddi, AL; Berlin, I; Ikeda, M; Nash, PD; et al. (2007). "Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor". Journal of immunology 179 (7): 4435–43. doi:10.4049/jimmunol.179.7.4435. PMID 17878339.
Machida, Kazuya; Thompson, Christopher M.; Dierck, Kevin; Jablonowski, Karl; Kärkkäinen, Satu; Liu, Bernard; Zhang, Haimin; Nash, Piers D.; et al. (2007). "High-Throughput Phosphotyrosine Profiling Using SH2 Domains". Molecular Cell 26 (6): 899–915. doi:10.1016/j.molcel.2007.05.031. PMID 17588523.
Sierra, M. I.; Wright, M. H.; Nash, P. D. (2010). "AMSH Interacts with ESCRT-0 to Regulate the Stability and Trafficking of CXCR4". Journal of Biological Chemistry 285 (18): 13990–4004. doi:10.1074/jbc.M109.061309. PMC 2859561. PMID 20159979.
Liu, B. A.; Jablonowski, K.; Shah, E. E.; Engelmann, B. W.; Jones, R. B.; Nash, P. D. (2010). "SH2 Domains Recognize Contextual Peptide Sequence Information to Determine Selectivity". Molecular & Cellular Proteomics 9 (11): 2391–2404. doi:10.1074/mcp.M110.001586.
Berlin, I.; Schwartz, H.; Nash, P. D. (2010). "Regulation of Epidermal Growth Factor Receptor Ubiquitination and Trafficking by the USP8{middle dot}STAM Complex". Journal of Biological Chemistry 285 (45): 34909–21. doi:10.1074/jbc.M109.016287. PMC 2966105. PMID 20736164.
Berlin, I.; Higginbotham, K. M.; Dise, R. S.; Sierra, M. I.; Nash, P. D. (2010). "The Deubiquitinating Enzyme USP8 Promotes Trafficking and Degradation of the Chemokine Receptor 4 at the Sorting Endosome". Journal of Biological Chemistry 285 (48): 37895–908. doi:10.1074/jbc.M110.129411. PMC 2988392. PMID 20876529.
Liu, B. A.; Shah, E.; Jablonowski, K.; Stergachis, A.; Engelmann, B.; Nash, P. D. (2011). "The SH2 Domain-Containing Proteins in 21 Species Establish the Provenance and Scope of Phosphotyrosine Signaling in Eukaryotes". Science Signaling 4 (202): ra83. doi:10.1126/scisignal.2002105. PMID 22155787. Lay summary – Science Life (13 December 2011).
Liu, Bernard A; Engelmann, Brett W; Jablonowski, Karl; Higginbotham, Katherine; Stergachis, Andrew B; Nash, Piers D (2012). "SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome". Cell Communication and Signaling 10 (1): 27. doi:10.1186/1478-811X-10-27. PMC 3514216. PMID 22974441.
Clarke, Michael; Lohan, Amanda J; Liu, Bernard; Lagkouvardos, Ilias; Roy, Scott; Zafar, Nikhat; Bertelli, Claire; Schilde, Christina; et al. (2013). "Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling". Genome Biology 14 (2): R11. doi:10.1186/gb-2013-14-2-r11. PMID 23375108.
Engelmann, Brett W.; Kim, Yohan; Wang, Miaoyan; Peters, Bjoern; Rock, Ronald S.; Nash, Piers D. (2014). "The development and application of a quantitative Peptide microarray based approach to protein interaction domain specificity space". Molecular & Cellular Proteomics 13 (12): 3647–3662. doi:10.1074/mcp.O114.038695. PMC 4256512. PMID 25135669.

Book Chapters

Nash, Piers; Lucas, Alexandra; McFadden, Grant (1997). "Serp-1, A Poxvirus-Encoded Serpin, Is Expressed as a Secreted Glycoprotein that Inhibits the Inflammatory Response to Myxoma Virus Infection". In Church, Frank C.; Cunningham, Dennis D.; Ginsburg, David; et al. Chemistry and Biology of Serpins. Advances in Experimental Medicine and Biology 425. pp. 195–205. doi:10.1007/978-1-4615-5391-5_19. ISBN 978-1-4613-7461-9.
Lalani, A.; Nash, P.; Seet, B.; Robichaud, J.; McFadden, G. (1999). "Interaction of DNA virus proteins with host cytokines". In Cann, A. DNA Viruses: A Practical Approach. Practical Approach Series. Oxford University Press. pp. 177–208.
Zalai, Christian V.; Nash, Piers; Dai, Erbin; Liu, Li Ying; Lucas, Alexandra (2002). "The Potential Role of Serine Proteinase Inhibitors for the Prevention of Plaque Rupture". In Brown, David L. Cardiovascular Plaque Rupture. CRC Press. pp. 447–82. ISBN 978-0-8247-0276-2.
Pawson, T.; Nash, P. (2003). "Modular protein interaction domains in cellular communication". Handbook of Cell Signaling 1. pp. 379–85.
Pawson, Tony; Gish, Gerald D.; Nash, Piers (2006). "The SH2 Domain: a Prototype for Protein Interaction Modules". In Cesareni, Giovanni; Gimona, Mario; Sudol, Marius; et al. Modular Protein Domains. Wiley. pp. 5–36. ISBN 978-3-527-60589-7.
Pawson, Tony; Nash, Piers (2011). "Modular Protein Interaction Domains in Cellular Communication". In Dennis, Edward A.; Bradshaw, Ralph A. Transduction Mechanisms in Cellular Signaling: Cell Signaling Collection. Academic Press. pp. 19–31. ISBN 978-0-12-383863-6.

Review Articles

Nash, Piers D.; Opas, Michal; Michalak, Marek (1994). "Calreticulin: Not just another calcium-binding protein". Molecular and Cellular Biochemistry 135 (1): 71–8. doi:10.1007/BF00925962. PMID 7816058.
McFadden, G; Graham, K; Ellison, K; Barry, M; Macen, J; Schreiber, M; Mossman, K; Nash, P; et al. (1995). "Interruption of cytokine networks by poxviruses: Lessons from myxoma virus". Journal of leukocyte biology 57 (5): 731–8. PMID 7759953.
McFadden, G.; Lalani, A.; Everett, H.; Nash, P.; Xu, X. (1998). "Virus-encoded receptors for cytokines and chemokines". Seminars in Cell & Developmental Biology 9 (3): 359–368. doi:10.1006/scdb.1998.0245.
Nash, Piers; Barrett, John; Cao, Jing-Xin; Hota-Mitchell, Sheela; Lalani, Alshad S.; Everett, Helen; Xu, Xiao-Ming; Robichaud, Janine; Hnatiuk, Shawna; Ainslie, Cheryl; Seet, Bruce T.; McFadden, Grant (1999). "Immunomodulation by viruses: The myxoma virus story". Immunological Reviews 168: 103–20. doi:10.1111/j.1600-065X.1999.tb01286.x. PMID 10399068.
Upton, C.; Macen, J.L.; Schreiber, M.; McFaddeni, G. (1991). "Myxoma virus expresses a secreted protein with homology to the tumor necrosis factor receptor gene family that contributes to viral virulence". Virology 184 (1): 370–82. doi:10.1016/0042-6822(91)90853-4. PMID 1651597.
Pawson, Tony; Nash, Piers (2000). "Protein–protein interactions define specificity in signal transduction". Genes & Development 14 (9): 1027–47. doi:10.1101/gad.14.9.1027 (inactive 2015-02-01). PMID 10809663.
Pawson, Tony; Gish, Gerald D; Nash, Piers (2001). "SH2 domains, interaction modules and cellular wiring". Trends in Cell Biology 11 (12): 504–11. doi:10.1016/S0962-8924(01)02154-7. PMID 11719057.
Pawson, Tony; Raina, Monica; Nash, Piers (2002). "Interaction domains: From simple binding events to complex cellular behavior". FEBS Letters 513 (1): 2–10. doi:10.1016/S0014-5793(01)03292-6. PMID 11911873.
Pawson, T.; Nash, P (2003). "Assembly of Cell Regulatory Systems Through Protein Interaction Domains". Science 300 (5618): 445–52. doi:10.1126/science.1083653. PMID 12702867.

This was the focus of the following review:

Gough, N. R.; Adler, E. M.; Ray, L. B. (2003). "Focus Issue: Cellular Regulation Through Protein Interaction Domains". Science Signaling 2003 (179): eg6. doi:10.1126/scisignal.1792003eg6.

Wright, Michelle H.; Berlin, Ilana; Nash, Piers D. (2011). "Regulation of Endocytic Sorting by ESCRT–DUB-Mediated Deubiquitination". Cell Biochemistry and Biophysics 60 (1–2): 39–46. doi:10.1007/s12013-011-9181-9. PMID 21448666.
Liu, Bernard A.; Engelmann, Brett W.; Nash, Piers D. (2012). "High-throughput analysis of peptide-binding modules". Proteomics 12 (10): 1527–46. doi:10.1002/pmic.201100599. PMID 22610655.
Liu, Bernard A.; Engelmann, Brett W.; Nash, Piers D. (2012). "The language of SH2 domain interactions defines phosphotyrosine-mediated signal transduction". FEBS Letters 586 (17): 2597–605. doi:10.1016/j.febslet.2012.04.054. PMID 22569091.
Nash, Piers D. (2012). "Why modules matter". FEBS Letters 586 (17): 2572–4. doi:10.1016/j.febslet.2012.04.049. PMID 22710154.
Liu, B. A.; Nash, P. D. (2012). "Evolution of SH2 domains and phosphotyrosine signalling networks". Philosophical Transactions of the Royal Society B: Biological Sciences 367 (1602): 2556–73. doi:10.1098/rstb.2012.0107. PMC 3415846. PMID 22889907.

Honors and awards

Paul Harris Fellow of Rotary International

Notes

↑ http://www.igsb.org Institute for Genomics and Systems Biology
↑ ResearchGate Profile of Piers Nash 30 October 2014 (see External Links)
↑ Scopus profile of Piers D. Nash 16 December 2014 (see External Links)

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