Piperlongumine

Piperlongumine
Names
IUPAC name
1-[(2E)-3-(3,4,5-Trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one
Other names
Piplartine
Identifiers
20069-09-4 N
ChEMBL ChEMBL465843 YesY
ChemSpider 553441 YesY
Jmol interactive 3D Image
PubChem 637858
Properties
C17H19NO5
Molar mass 317.34 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Piperlongumine (PL) is a natural product constituent of the fruit of the Long pepper (Piper longum),[1] a pepper plant found in southern India and southeast Asia.

Piperlongumine may have anti-cancer properties. In in vitro experiments, it selectively kills some types cancer cells over normal cells.[1] One study in a xenograft mouse model of cancer showed that piperlongumine inhibits the growth of malignant breast tumors and their associated metastases.[1][2]

References

  1. 1 2 3 Raj, Lakshmi; Ide, Takao; Gurkar, Aditi U.; Foley, Michael; Schenone, Monica; Li, Xiaoyu; Tolliday, Nicola J.; Golub, Todd R.; et al. (2011). "Selective killing of cancer cells by a small molecule targeting the stress response to ROS". Nature 475 (7355): 231–234. doi:10.1038/nature10167. PMC 3316487. PMID 21753854.
  2. "Novel Compound Selectively Kills Cancer Cells by Blocking Their Response to Oxidative Stress". ScienceDaily. July 2011.

External links

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