Plasma kallikrein

Plasma kallikrein
Identifiers
EC number 3.4.21.34
CAS number 410538-33-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Plasma kallikrein (EC 3.4.21.34, serum kallikrein, kininogenin, kallikrein I, kallikrein II, kininogenase, kallikrein, callicrein, glumorin, padreatin, padutin, kallidinogenase, bradykininogenase, panceatic kallikrein, onokrein P, dilminal D, depot-Padutin, urokallikrein, urinary kallikrein) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Selective cleavage of some Arg- and Lys- bonds, including Lys-Arg and Arg-Ser in (human) kininogen to release bradykinin

This enzyme is formed from plasma prokallikrein (Fletcher factor) by factor XIIa.

See also

References

  1. ↑ Heimark, R.L. and Davie, E.W. (1981). "Bovine and human plasma prekallikrein". Methods Enzymol. 80: 157–172. doi:10.1016/s0076-6879(81)80016-x. PMID 6918767.
  2. ↑ McRae, B.J., Kurachi, K., Heimark, R.L., Fujikawa, K., Davie, E.W. and Powers, J.C. (1981). "Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates". Biochemistry 20: 7196–7206. doi:10.1021/bi00528a022. PMID 6976185.
  3. ↑ Silverberg, M. and Kaplan, A.P. (1988). "Prekallikrein". Methods Enzymol. 163: 85–95. doi:10.1016/0076-6879(88)63010-2. PMID 3237096.
  4. ↑ Seidah, N.G., Ladenheim, R., Mbikay, M., Hamelin, J., Lutfalla, G., Rougeon, F., Lazure, C. and Chrétien, M. (1989). "The cDNA structure of rat plasma kallikrein". DNA 8: 563–574. doi:10.1089/dna.1989.8.563. PMID 2598771.
  5. ↑ Tsuda, Y., Teno, N., Okada, Y., Wanaka, K., Bohgaki, M., Hijikata-Okunomiya, A., Okamoto, U., Naito, T. and Okamoto, S. (1989). "Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein". Chem. Pharm. Bull. 37: 3108–3111. doi:10.1248/cpb.37.3108. PMID 2534361.

External links

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