Plasmepsin I

Plasmepsin I
Identifiers
EC number	3.4.23.38
CAS number	180189-87-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Plasmepsin I (EC 3.4.23.38, aspartic hemoglobinase I, PFAPG, malaria aspartic hemoglobinase) is an enzyme.^[1][2][3] This enzyme catalyses the following chemical reaction

Hydrolysis of the -Phe³³-Leu- bond in the alpha-chain of hemoglobin, leading to denaturation of the molecule

This enzyme is present in the malaria organism, Plasmodium.

References

1. Goldberg, D.E., Slater, A.F.G., Beavis, R., Chait, B., Cerami, A. and Henderson, G.B. (1991). "Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease". J. Exp. Med. 173 (4): 961–969. doi:10.1084/jem.173.4.961. PMID 2007860.
2. Francis, S.E., Gluzman, I.Y., Oksman, A., Knickerbocker, A., Mueller, R., Bryant, M.L., Sherman, D.R., Russell, D.G. and Goldberg, D.E. (1994). "Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase". EMBO J. 13 (2): 306–317. PMID 8313875.
3. Gluzman, I.Y., Francis, S.E., Oksman, A., Smith, C.E., Duffin, K.L. and Goldberg, D.E. (1994). "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". J. Clin. Invest. 93: 1602–1608. doi:10.1172/JCI117140. PMID 8163662.

External links

• Plasmepsin I at the US National Library of Medicine Medical Subject Headings (MeSH)