Plasmepsin II
Plasmepsin II (EC 3.4.23.39, aspartic hemoglobinase II, PFAPD) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe-Phe(NO2)-Ser-Phe-Pro-Thr
This enzyme is present in malaria organism, Plasmodium.
References
- ↑ Dame, J.B., Reddy, G.R., Yowell, C.A., Dunn, B.M., Kay, J. and Berry, C. (1994). "Sequence, expression and modelled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum". Mol. Biochem. Parasitol. 64: 177–190. doi:10.1016/0166-6851(94)90024-8. PMID 7935597.
- ↑ Gluzman, I.Y., Francis, S.E., Oksman, A., Smith, C.E., Duffin, K.L. and Goldberg, D.E. (1994). "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". J. Clin. Invest. 93 (4): 1602–1608. doi:10.1172/JCI117140. PMID 8163662.
- ↑ Hill, J., Tyas, L., Phylip, L.H., Kay, J., Dunn, B.M. and Berry, C. (1994). "High level expression and characterisation of plasmepsin II, an aspartic proteinase from Plasmodium falciparum". FEBS Lett. 352 (2): 155–158. doi:10.1016/0014-5793(94)00940-6. PMID 7925966.
External links
|
---|
| Activity | |
---|
| Regulation | |
---|
| Classification | |
---|
| Types | |
---|
|