Pleuran

Pleuran

Identifiers
CAS Number	159940-37-1
Properties
Chemical formula	(C6H10O5)x
Molar mass	Variable
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Pleuran is an insoluble polysaccharide (β-(1,3/1,6)-D-glucan), isolated from Pleurotus ostreatus.^[1]

Pleuran belongs to a group of glucose polymers commonly called beta-glucans demonstrating biological response modifier properties. These immunomodulating properties render the host more resistant to infections and neoplasms.^[2]

In a study published in December 2010, pleuran demonstrated to have a protective effect against exercise-induced suppression of immune cell activity (NK cells) in subjects taking 100 mg per day.^[3]

In another study published in 2011, pleuran reduced the incidence of upper respiratory tract infections and increased the number of circulating NK cells.^[4]

Pleuran is also being studied as a potential immunologic adjuvant.^[5]

References

1. Karácsonyi S, Kuniak L (1994). "Polysaccharides of Pleurotus ostreatus: Isolation and structure of pleuran, an alkali-insoluble β-glucan". Carbohydrate Polymers (Elsevier) 24 (2): 107–111. doi:10.1016/0144-8617(94)90019-1.
2. Di Luzio, NR (1985). "Update on the immunomodulating activities of glucans". Springer seminars in immunopathology (Germany: Springer Verlag) 8 (4): 387–400. doi:10.1007/BF01857392. PMID 4089757.
3. Bobovčák, M; Kuniaková, R, Gabriž, J, Majtán, J (December 2010). "Effect of Pleuran (β-glucan from Pleurotus ostreatus) supplementation on cellular immune response after intensive exercise in elite athletes.". Applied Physiology, Nutrition, and Metabolism 35 (6): 755–62. doi:10.1139/h10-070. PMID 21164546.
4. Bergendiova, K; Tibenska, E, Majtan, J (2011-01-20). "Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes.". European journal of applied physiology 111 (9): 2033–40. doi:10.1007/s00421-011-1837-z. PMID 21249381.
5. Vogel FR, Powell MF, Alving CR (1998). "A Compendium of Vaccine Adjuvants and Excipients" (PDF). 2nd ed. National Institute of Allergy and Infectious Diseases: 77. Retrieved 2008-05-08.