PLXNB1

Plexin B1
Rendering based on PDB 2JPH​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2JPH​, 2OS6​, 2R2O​, 2REX​, 3HM6​, 3OL2​, 3SU8​, 3SUA​
Identifiers
Symbols	PLXNB1 ; PLEXIN-B1; PLXN5; SEP
External IDs	OMIM: 601053 MGI: 2154238 HomoloGene: 130508 GeneCards: PLXNB1 Gene
Gene ontology Molecular function • receptor activity • transmembrane signaling receptor activity • protein binding • semaphorin receptor activity • semaphorin receptor binding • GTPase activating protein binding Cellular component • semaphorin receptor complex • extracellular region • intracellular • plasma membrane • integral component of plasma membrane Biological process • negative regulation of cell adhesion • signal transduction • axon guidance • regulation of cell shape • positive regulation of phosphatidylinositol 3-kinase signaling • cell migration • negative regulation of osteoblast proliferation • intracellular signal transduction • positive regulation of GTPase activity • ossification involved in bone maturation • neuron projection morphogenesis • positive regulation of axonogenesis • regulation of cytoskeleton organization • semaphorin-plexin signaling pathway • semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5364	235611
Ensembl	ENSG00000164050	ENSMUSG00000053646
UniProt	O43157	Q8CJH3
RefSeq (mRNA)	NM_001130082	NM_172775
RefSeq (protein)	NP_001123554	NP_766363
Location (UCSC)	Chr 3: 48.4 – 48.43 Mb	Chr 9: 109.1 – 109.12 Mb
PubMed search

Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.^[1][2][3]

Function

Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins.^[4] Outside of neural tissues, Plexin B1 is implicated in the control of cell migration.^[5]

Interactions

PLXNB1 has been shown to interact with ARHGEF12,^[6] Rnd1^[7] and ARHGEF11.^[6][7][8][9]

References

1. Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci U S A 93 (2): 674–8. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614.
2. Vikis HG, Li W, He Z, Guan KL (Nov 2000). "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner". Proc Natl Acad Sci U S A 97 (23): 12457–62. doi:10.1073/pnas.220421797. PMC 18785. PMID 11035813.
3. "Entrez Gene: PLXNB1 plexin B1".
4. Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (Oct 9, 2002). "B plexins activate Rho through PDZ-RhoGEF.". FEBS Letters 529 (2-3): 168–72. doi:10.1016/s0014-5793(02)03323-9. PMID 12372594.
5. Basile JR, Afkhami T, Gutkind JS (Aug 2005). "Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway.". Molecular and Cellular Biology 25 (16): 6889–98. doi:10.1128/mcb.25.16.6889-6898.2005. PMC 1190270. PMID 16055703.
6. Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (Sep 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504.
7. Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
8. Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
9. Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.

Further reading

• Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
• Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
• Vikis HG, Li W, Guan KL (2002). "The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding". Genes Dev. 16 (7): 836–45. doi:10.1101/gad.966402. PMC 186329. PMID 11937491.
• Swiercz JM, Kuner R, Behrens J, Offermanns S (2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.
• Perrot V, Vazquez-Prado J, Gutkind JS (2003). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
• Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL (2002). "The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12085–90. doi:10.1073/pnas.142433199. PMC 129402. PMID 12196628.
• Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D, Tamagnone L, Comoglio PM (2002). "The semaphorin 4D receptor controls invasive growth by coupling with Met". Nat. Cell Biol. 4 (9): 720–4. doi:10.1038/ncb843. PMID 12198496.
• Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504.
• Granziero L, Circosta P, Scielzo C, Frisaldi E, Stella S, Geuna M, Giordano S, Ghia P, Caligaris-Cappio F (2003). "CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes". Blood 101 (5): 1962–9. doi:10.1182/blood-2002-05-1339. PMID 12406905.
• Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L (2003). "Functional regulation of semaphorin receptors by proprotein convertases". J. Biol. Chem. 278 (12): 10094–101. doi:10.1074/jbc.M210156200. PMID 12533544.
• Usui H, Taniguchi M, Yokomizo T, Shimizu T (2003). "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains". Biochem. Biophys. Res. Commun. 300 (4): 927–31. doi:10.1016/S0006-291X(02)02966-2. PMID 12559962.
• Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
• Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene 23 (30): 5131–7. doi:10.1038/sj.onc.1207650. PMID 15184888.
• Swiercz JM, Kuner R, Offermanns S (2004). "Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2". J. Cell Biol. 165 (6): 869–80. doi:10.1083/jcb.200312094. PMC 2172401. PMID 15210733.
• Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science 305 (5685): 862–5. doi:10.1126/science.1097545. PMID 15297673.
• Conrotto P, Valdembri D, Corso S, Serini G, Tamagnone L, Comoglio PM, Bussolino F, Giordano S (2005). "Sema4D induces angiogenesis through Met recruitment by Plexin B1". Blood 105 (11): 4321–9. doi:10.1182/blood-2004-07-2885. PMID 15632204.