Polar overdominance

Polar overdominance is a unique form of inheritance (described in sheep) whereby a mutant Callipyge allele must be inherited from the father to cause muscle hypertrophy.Muscle hypertrophy in the offspring is caused by an increase in the size of all skeletal muscle fibers, with the exception of slow twitch muscle fibers. This increase is generally located in the hind quarters and torso. Muscle hypertrophy only manifests itself in the offspring approximately one month after birth.[1]

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References

  1. M Georges, N Cockett. The ovine callipyge locus: a paradigm illustrating the importance of non-Mendelian genetics in livestock. Reproduction Nutrition Development, EDP Sciences, 1996, 36 (6), pp.651-657.


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