Mepivacaine

Mepivacaine

Systematic (IUPAC) name
(RS)-N-(2,6-dimethylphenyl)- 1-methyl-piperidine-2-carboxamide
Clinical data
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a603026
Pregnancy category	C, use w/ caution, may cause fetal bradycardia
Identifiers
CAS Number	96-88-8
ATC code	N01BB03 (WHO)
PubChem	CID 4062
IUPHAR/BPS	7224
DrugBank	DB00961
ChemSpider	3922
UNII	B6E06QE59J
KEGG	D08181
ChEBI	CHEBI:6759
ChEMBL	CHEMBL1087
Chemical data
Formula	C15H22N2O
Molar mass	246.348 g/mol
SMILES O=C(Nc1c(cccc1C)C)C2N(C)CCCC2
InChI InChI=1S/C15H22N2O/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18) Key:INWLQCZOYSRPNW-UHFFFAOYSA-N
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Mepivacaine /mɛˈpɪvəkeɪn/ is a local anesthetic^[1] of the amide type. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine) and is marketed under various trade names including Carbocaine and Polocaine.

Mepivacaine became available in the United States in the 1960s.

Mepivacaine is used in any infiltration and regional anesthesia.

It is supplied as the hydrochloride salt of the racemate.^[2]

References

1. Porto GG, Vasconcelos BC, Gomes AC, Albert D (January 2007). "Evaluation of lidocaine and mepivacaine for inferior third molar surgery" (PDF). Med Oral Patol Oral Cir Bucal 12 (1): E60–4. PMID 17195831.
2. Burm AG, Cohen IM, van Kleef JW, Vletter AA, Olieman W, Groen K (January 1997). "Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers". Anesth. Analg. 84 (1): 85–9. doi:10.1097/00000539-199701000-00016. PMID 8989005.

External links

• Mepivacaine at RxList