Polyamine oxidase

polyamine oxidase
Identifiers
EC number	1.5.3.11
CAS number	294646-71-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a polyamine oxidase (EC 1.5.3.11) is an enzyme that catalyzes the chemical reaction

N₁-acetylspermine + O₂ + H₂O $\rightleftharpoons$ N₁-acetylspermidine + 3-aminopropanal + H₂O₂

The 3 substrates of this enzyme are N1-acetylspermine, O₂, and H₂O, whereas its 3 products are N1-acetylspermidine, 3-aminopropanal, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N1-acetylspermidine:oxygen oxidoreductase (deaminating). This enzyme is also called 1-N-acetylspermidine:oxygen oxidoreductase (deaminating). It has 2 cofactors: FAD, and Iron. A similar enzyme in plants catalyzes non-acetylated polyamines.^[1]

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1B37, 1H81, 1H82, 1H83, 1H84, 1H86, 1RSG, 1YY5, and 1Z6L.

References

1. Moschou, Panagiotis; Maite Sanmartin; Athina H Andriopoulou; Enrique Rojo; Jose J Sanchez-Serrano; Kalliopi A Roubelakis-Angelakis (1 August 2008). "Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis". plant physiology 147 (4): 1845–1857.

• Bolkenius FN, Seiler N (1981). "Acetylderivatives as intermediates in polyamine catabolism". Int. J. Biochem. 13 (3): 287–292. doi:10.1016/0020-711X(81)90080-X. PMID 7215618.
• Holtta E (1983). "Polyamine oxidase (rat liver)". Methods Enzymol. Methods in Enzymology 94: 306–311. doi:10.1016/S0076-6879(83)94054-5. ISBN 978-0-12-181994-1. PMID 6621391.