Polyamine oxidase (propane-1,3-diamine-forming)

Polyamine oxidase (propane-1,3-diamine-forming) (EC 1.5.3.14, MPAO, maize PAO) is an enzyme with systematic name spermidine:oxygen oxidoreductase (propane-1,3-diamine-forming).^[1]^[2] This enzyme catalyses the following chemical reaction

spermidine + O₂ + H₂O

\rightleftharpoons

propane-1,3-diamine + 4-aminobutanal + H₂O₂

The products of the reaction cannot be converted directly to other polyamines.

References

↑ Tavladoraki, P., Schinina, M.E., Cecconi, F., Di Agostino, S., Manera, F., Rea, G., Mariottini, P., Federico, R. and Angelini, R. (1998). "Maize polyamine oxidase: primary structure from protein and cDNA sequencing". FEBS Lett. 426: 62–66. doi:10.1016/S0014-5793(98)00311-1. PMID 9598979.
↑ Federico, R., Ercolini, L., Laurenzi, M., Angelini, R. (1996). "Oxidation of acetylpolyamines by maize polyamine oxidase". Phytochemistry 43: 339–341. doi:10.1016/0031-9422(96)00316-0.

External links

Polyamine oxidase (propane-1,3-diamine-forming) at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: CH-NH (EC 1.5)

1.5.1: NAD or NADP acceptor	Dihydrofolate reductase Saccharopine dehydrogenase Methylenetetrahydrofolate reductase

1.5.3: oxygen acceptor	Dihydrobenzophenanthridine oxidase Sarcosine oxidase Proline oxidase

1.5.5: quinone acceptor	Electron-transferring-flavoprotein dehydrogenase

1.5.99	Sarcosine dehydrogenase Cytokinin dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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