Prolactin-releasing peptide

Prolactin releasing hormone
Identifiers
Symbols	PRLH ; PRH; PRRP
External IDs	OMIM: 602663 MGI: 3644668 HomoloGene: 9291 GeneCards: PRLH Gene
Gene ontology Molecular function • hormone activity • neuropeptide hormone activity • prolactin-releasing peptide receptor binding Cellular component • extracellular region • cytoplasm Biological process • tissue homeostasis • reduction of food intake in response to dietary excess • energy reserve metabolic process • lipid metabolic process • G-protein coupled receptor signaling pathway • response to glucose • response to insulin • regulation of multicellular organism growth • fat cell differentiation • autonomic nervous system development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51052	623503
Ensembl	ENSG00000071677	ENSMUSG00000090550
UniProt	P81277	G3UWC3
RefSeq (mRNA)	NM_015893	NM_001101647
RefSeq (protein)	NP_056977	NP_001095117
Location (UCSC)	Chr 2: 237.57 – 237.57 Mb	Chr 1: 90.95 – 90.95 Mb
PubMed search

Prolactin-releasing peptide (PrRP) is a peptide hormone that in humans is encoded by the PRLH gene.^[1] PrRP stimulates prolactin (PRL) release and regulates the expression of prolactin through binding to the prolactin-releasing peptide receptor (GPR10).^[2]

References

1. "Entrez Gene: PRLH prolactin releasing hormonel".
2. Langmead CJ, Szekeres PG, Chambers JK, Ratcliffe SJ, Jones DN, Hirst WD, Price GW, Herdon HJ (October 2000). "Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor". Br. J. Pharmacol. 131 (4): 683–8. doi:10.1038/sj.bjp.0703617. PMC 1572376. PMID 11030716.

Further reading

• Hinuma S, Onda H, Fujino M (1999). "The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors.". J. Mol. Med. 77 (6): 495–504. doi:10.1007/s001090050403. PMID 10475064.
• Lagerström MC, Fredriksson R, Bjarnadottir TK, Schiöth HB (2006). "The ancestry of the prolactin-releasing hormone precursor.". Ann. N. Y. Acad. Sci. 1040: 368–70. doi:10.1196/annals.1327.064. PMID 15891064.
• Hinuma S, Habata Y, Fujii R, et al. (1998). "A prolactin-releasing peptide in the brain.". Nature 393 (6682): 272–6. doi:10.1038/30515. PMID 9607765.
• Fujii R, Fukusumi S, Hosoya M, et al. (1999). "Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor.". Regul. Pept. 83 (1): 1–10. doi:10.1016/S0167-0115(99)00028-2. PMID 10498338.
• Zhang X, Danila DC, Katai M, et al. (2000). "Expression of prolactin-releasing peptide and its receptor messenger ribonucleic acid in normal human pituitary and pituitary adenomas.". J. Clin. Endocrinol. Metab. 84 (12): 4652–5. doi:10.1210/jc.84.12.4652. PMID 10599733.
• Yasui Y, Yamaguchi M, Jikihara H, et al. (2002). "Expression of prolactin-releasing peptide in human placenta and decidua". Endocr. J. 48 (3): 397–401. doi:10.1507/endocrj.48.397. PMID 11523913.
• Takahashi K, Totsune K, Murakami O, et al. (2003). "Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas". Peptides 23 (6): 1135–40. doi:10.1016/S0196-9781(02)00046-3. PMID 12126742.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.